23284-84-6

Basic information

• Product Name: Methyl N-phenylglycinate
• Synonyms: Methyl N-phenylglycinate;N-Phenyl-glycine methyl ester
• CAS NO: 23284-84-6
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.18914
• Mol File: 23284-84-6.mol
• Article Data: 24

Chemical Properties

• Appearance: /
• Storage Temp.: Room Temperature, under inert atmosphere
• Solubility: Acetonitrile (Slightly), DMSO (Slightly)
• CAS DataBase Reference: Methyl N-phenylglycinate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl N-phenylglycinate(23284-84-6)
• EPA Substance Registry System: Methyl N-phenylglycinate(23284-84-6)

Safety Data

• Hazardous Substances Data: 23284-84-6(Hazardous Substances Data)

Usage

General Description

Methyl N-phenylglycinate, also known as N-methyl glycine phenyl ester, is an organic compound with the chemical formula C9H11NO2. It is a white crystalline solid that is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. Methyl N-phenylglycinate is derived from the amino acid glycine and has a methyl group attached to the nitrogen atom. Methyl N-phenylglycinate has a wide range of applications, including as a precursor in the production of pharmaceuticals, as a fragrance and flavor ingredient in the cosmetic and food industries, and as an intermediate in the synthesis of insecticides and herbicides. It is important to handle and store this compound with care, as it may pose health and environmental hazards if not properly managed.

Upstream product

• 186581-53-3 diazomethane 
• 103-01-5 N-Phenylglycine 
• 16695-14-0 Malonic acid monomethyl ester 
• 62-53-3 aniline 
• 51673-84-8 dimethoxyacetaldehyde 
• 591-50-4 iodobenzene 
• 616-34-2 methoxycarbonylmethylamine 
• 108-59-8 malonic acid dimethyl ester 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 96-32-2 bromoacetic acid methyl ester 
• 67-56-1 methanol 
• 598-21-0 2-Bromoacetyl bromide 
• 96-34-4 methyl chloroacetate 

Downstream Products

• 40969-51-5 N-(chloroacetyl)-N-phenylglycine 
• 116836-29-4 N-chloroacetyl-N-phenyl-glycine methyl ester 
• 18030-26-7 [(3,5-Dibromo-2-diacetylamino-benzyl)-phenyl-amino]-acetic acid methyl ester 
• 18053-20-8 [(2-Acetylamino-6-chloro-benzyl)-phenyl-amino]-acetic acid 
• 21649-19-4 1-Methoxycarbonyl-methyl-1.3-diphenyl-harnstoff 
• 18030-42-7 [(5-Chloro-2-diacetylamino-benzyl)-phenyl-amino]-acetic acid methyl ester 
• 106369-05-5 (3aS,6aR)-4,6-Dioxo-2-phenyl-5-p-tolyl-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid methyl ester 
• 111098-88-5 (1R,3R,3aS,6aR)-4,6-Dioxo-2,3-diphenyl-5-p-tolyl-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid methyl ester 
• 111098-88-5 (1S,3S,3aS,6aR)-4,6-Dioxo-2,3-diphenyl-5-p-tolyl-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid methyl ester 
• 111098-90-9 (1S,3R,3aR,6aS)-3-Ethyl-4,6-dioxo-2-phenyl-5-p-tolyl-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid methyl ester 
• 111098-90-9 (1R,3S,3aR,6aS)-3-Ethyl-4,6-dioxo-2-phenyl-5-p-tolyl-octahydro-pyrrolo[3,4-c]pyrrole-1-carboxylic acid methyl ester 
• 113729-07-0 3-Phenyl-oxazolidine-4-carboxylic acid methyl ester 
• 147749-05-1 3-hydroxy-1-methoxycarbonyl-2-oxo-3-trifluoromethylindoline 
• 111098-96-5 (2S,3S,4R,5R)-4-Nitro-1,3,5-triphenyl-pyrrolidine-2-carboxylic acid methyl ester 

Relevant articles and documents

Discovery of 2-oxopiperazine dengue inhibitors by scaffold morphing of a phenotypic high-throughput screening hit

A series of 2-oxopiperazine derivatives were designed from the pyrrolopiperazinone cell-based screening hit 4 as a dengue virus inhibitor. Systematic investigation of the structure-activity relationship (SAR) around the piperazinone ring led to the identification of compound (S)-29, which exhibited potent anti-dengue activity in the cell-based assay across all four dengue serotypes with EC50??0.1?μM. Cross-resistant analysis confirmed that the virus NS4B protein remained the target of the new oxopiperazine analogs obtained via scaffold morphing from the HTS hit 4.

Visible-Light-Induced Oxidative α-Alkylation of Glycine Derivatives with Ethers under Metal-Free Conditions

In this work, a visible-light-induced oxidative α-alkylation of glycine derivatives with ethers has been developed in the presence of catalytic Eosin Y. Under the blue light of a 3 W LED, a range of α-etherized glycine derivatives, including α-amino esters, α-amino ketones and α-amino amides, were achieved with good to excellent yields and functional group tolerance with tert-butyl hydroperoxide (TBHP) as oxidant at ambient temperature. The operationally easy procedure provides an economical, metal-free, and mild alternative for the synthesis of the α-etherized glycine derivatives.

Al(OTf)3-Catalyzed Tandem Coupling Reaction between N,N-Disubstituted Aminomalonitriles and Substituted Arenes: a Synthesis of 1-Cyano-bisindolylmethane Analogues≠

A synthesis of 1-cyano-bisindolylmethane analogues via an Al(OTf)3-catalyzed tandem coupling reaction between N,N-disubstituted aminomalonitriles and substituted arenes has been developed. This method not only provides an alternative synthetic strategy for the synthesis of corresponding functional molecules, but also enriches the volume of bisarylmethanes library to facilitate related functional studies. (Figure presented.).