C₂₀H₂₀BrFN₂O₆S

Base Information

Chemical Name:C₂₀H₂₀BrFN₂O₆S
CAS No.:1386985-89-2
Molecular Formula:C₂₀H₂₀BrFN₂O₆S
Molecular Weight:515.357
Hs Code.:

C<sub>20</sub>H<sub>20</sub>BrFN<sub>2</sub>O<sub>6</sub>S

Synonyms:

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Chemical Property of C₂₀H₂₀BrFN₂O₆S

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Technology Process of C₂₀H₂₀BrFN₂O₆S

There total 6 articles about C₂₀H₂₀BrFN₂O₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 460-00-4
1-Bromo-4-fluorobenzene

: 1386985-89-2
C₂₀H₂₀BrFN₂O₆S

: 1386985-91-6
C₂₀H₂₀BrFN₂O₆S

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 2.5 h / -70 - -60 °C

1.2: 0.25 h / -70 - -50 °C

1.3: -70 °C

2.1: 3,5-bis-trifluoromethyl-benzoic acid (R)-(6-hydroxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl ester / dichloromethane / 72 h / -25 - -20 °C

3.1: zinc; acetic acid / 0.25 h / 30 - 40 °C

4.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

4.2: Inert atmosphere

5.1: potassium carbonate; potassium hydrogencarbonate / acetonitrile / 2 h

6.1: camphor-10-sulfonic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

7.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 2.5 h / 0 - 20 °C

With n-butyllithium; dimethylsulfide borane complex; camphor-10-sulfonic acid; potassium carbonate; potassium hydrogencarbonate; acetic acid; diisopropylamine; triphenylphosphine; zinc; diethylazodicarboxylate; 3,5-bis-trifluoromethyl-benzoic acid (R)-(6-hydroxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl ester; In tetrahydrofuran; hexane; dichloromethane; toluene; acetonitrile;

Reference yield:

: 668969-68-4
ethyl 2-(5-bromo-2-fluorophenyl)-2-oxoacetate

: 1386985-89-2
C₂₀H₂₀BrFN₂O₆S

: 1386985-91-6
C₂₀H₂₀BrFN₂O₆S

Guidance literature:: Multi-step reaction with 6 steps

1.1: 3,5-bis-trifluoromethyl-benzoic acid (R)-(6-hydroxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl ester / dichloromethane / 72 h / -25 - -20 °C

2.1: zinc; acetic acid / 0.25 h / 30 - 40 °C

3.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

3.2: Inert atmosphere

4.1: potassium carbonate; potassium hydrogencarbonate / acetonitrile / 2 h

5.1: camphor-10-sulfonic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

6.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 2.5 h / 0 - 20 °C

With dimethylsulfide borane complex; camphor-10-sulfonic acid; potassium carbonate; potassium hydrogencarbonate; acetic acid; triphenylphosphine; zinc; diethylazodicarboxylate; 3,5-bis-trifluoromethyl-benzoic acid (R)-(6-hydroxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methyl ester; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;

Reference yield:

: 1386984-46-8
(R)-2-(5-bromo-2-fluoro-phenyl)-2-hydroxy-3-nitro-propionic acid ethyl ester

: 1386985-89-2
C₂₀H₂₀BrFN₂O₆S

: 1386985-91-6
C₂₀H₂₀BrFN₂O₆S

Guidance literature:: Multi-step reaction with 5 steps

1.1: zinc; acetic acid / 0.25 h / 30 - 40 °C

2.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / Inert atmosphere; Reflux

2.2: Inert atmosphere

3.1: potassium carbonate; potassium hydrogencarbonate / acetonitrile / 2 h

4.1: camphor-10-sulfonic acid / dichloromethane / 2 h / 20 °C / Cooling with ice

5.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 2.5 h / 0 - 20 °C

With dimethylsulfide borane complex; camphor-10-sulfonic acid; potassium carbonate; potassium hydrogencarbonate; acetic acid; triphenylphosphine; zinc; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;