Diphenyl-carbamic acid 9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[chloro-(2-cyano-ethoxy)-phosphanyloxy]-tetrahydro-furan-2-yl}-2-propionylamino-9H-purin-6-yl ester

Base Information

• Chemical Name: Diphenyl-carbamic acid 9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[chloro-(2-cyano-ethoxy)-phosphanyloxy]-tetrahydro-furan-2-yl}-2-propionylamino-9H-purin-6-yl ester
• CAS No.: 130983-91-4
• Molecular Formula: C₅₀H₄₇ClN₇O₉P
• Molecular Weight: 956.391

Synonyms:

Chemical Property of Diphenyl-carbamic acid 9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[chloro-(2-cyano-ethoxy)-phosphanyloxy]-tetrahydro-furan-2-yl}-2-propionylamino-9H-purin-6-yl ester

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Technology Process of Diphenyl-carbamic acid 9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[chloro-(2-cyano-ethoxy)-phosphanyloxy]-tetrahydro-furan-2-yl}-2-propionylamino-9H-purin-6-yl ester

There total 1 articles about Diphenyl-carbamic acid 9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[chloro-(2-cyano-ethoxy)-phosphanyloxy]-tetrahydro-furan-2-yl}-2-propionylamino-9H-purin-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-cyanoethyl 5'-O-dimethoxytrityl-N2-propionyl-O6-diphenylcarbamoyldeoxyguanosin-3'-yl phosphonate (130983-90-3) → Diphenyl-carbamic acid 9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[chloro-(2-cyano-ethoxy)-phosphanyloxy]-tetrahydro-furan-2-yl}-2-propionylamino-9H-purin-6-yl ester (130983-91-4)

Guidance literature:

With pyridine; perdeuteriopyridine; tris(2,4,6-tribromo-phenoxy)dichlorophosphorane; for 0.0833333h;

DOI:10.1021/jo00003a056

Reference yield:

Diphenyl-carbamic acid 9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[chloro-(2-cyano-ethoxy)-phosphanyloxy]-tetrahydro-furan-2-yl}-2-propionylamino-9H-purin-6-yl ester (130983-91-4) → C50H47N7O11P(1-) (130954-80-2)

Guidance literature:

With water; iodine; In pyridine; perdeuteriopyridine; for 0.166667h;

DOI:10.1021/jo00003a056

Reference yield:

3,3'-O,N-dibenzoylthymidine (94189-81-8) + Diphenyl-carbamic acid 9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[chloro-(2-cyano-ethoxy)-phosphanyloxy]-tetrahydro-furan-2-yl}-2-propionylamino-9H-purin-6-yl ester (130983-91-4) → C74H68N9O16P (130983-92-5)

Guidance literature:

With pyridine; perdeuteriopyridine; for 0.0833333h;

DOI:10.1021/jo00003a056

upstream raw materials:

2-cyanoethyl 5'-O-dimethoxytrityl-N²-propionyl-O⁶-diphenylcarbamoyldeoxyguanosin-3'-yl phosphonate

Downstream raw materials:

C₇₄H₆₈N₉O₁₆P

C₅₀H₄₇N₇O₁₁P^(1-)

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