Technology Process of 1-ethyl-4-(2-phenylethyl)-2,3-dihydro-1H-indole
There total 7 articles about 1-ethyl-4-(2-phenylethyl)-2,3-dihydro-1H-indole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1) NaOMe / 1) Et2O, 1h, 2) overnight, r.t.
2: 120 mg / H2 / Pd/C / methanol; CH2Cl2 / 0.75 h / 760 Torr / Ambient temperature
3: 89 percent / NaBH4 / 1) r.t., 1h, 2) 60 - 70 deg C
With
sodium tetrahydroborate; hydrogen; sodium methylate;
palladium on activated charcoal;
In
methanol; dichloromethane;
DOI:10.1002/ardp.19903230305
- Guidance literature:
-
Multi-step reaction with 7 steps
1: SOCl2
2: H2O
3: 96.5 percent / BF3*Et2O / CHCl3 / 0.5 h / Ambient temperature
4: 1) pyrrolidine, 2) hydrazine hydrate / 2) Raney-Ni / 1) DMF, 135 deg C, 3h, 2) THF/MeOH, 2-propanol, 50 deg C, 3h
5: 1) NaOMe / 1) Et2O, 1h, 2) overnight, r.t.
6: 120 mg / H2 / Pd/C / methanol; CH2Cl2 / 0.75 h / 760 Torr / Ambient temperature
7: 89 percent / NaBH4 / 1) r.t., 1h, 2) 60 - 70 deg C
With
pyrrolidine; sodium tetrahydroborate; thionyl chloride; water; hydrogen; sodium methylate; hydrazine hydrate;
palladium on activated charcoal; boron trifluoride diethyl etherate; nickel;
In
methanol; dichloromethane; chloroform;
DOI:10.1002/ardp.19903230305
