[2-(Benzyloxy)phenyl]acetyl chloride

Base Information

• Chemical Name: [2-(Benzyloxy)phenyl]acetyl chloride
• CAS No.: 115439-34-4
• Molecular Formula: C15H13ClO2
• Molecular Weight: 260.72
• DSSTox Substance ID: DTXSID90550468
• Wikidata: Q82429845
• Mol file: 115439-34-4.mol

Synonyms:115439-34-4;[2-(Benzyloxy)phenyl]acetyl chloride;2-benzyloxyphenylacetyl chloride;SCHEMBL1462035;DTXSID90550468;2-(2-(Benzyloxy)phenyl)acetyl chloride

Chemical Property of [2-(Benzyloxy)phenyl]acetyl chloride

Chemical Property:

• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 260.0604073
• Heavy Atom Count: 18
• Complexity: 261

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC=CC=C2CC(=O)Cl

Technology Process of [2-(Benzyloxy)phenyl]acetyl chloride

There total 2 articles about [2-(Benzyloxy)phenyl]acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl bromide (100-39-0) → (2-benzyloxy-phenyl)-acetyl chloride (115439-34-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / Reflux

2: thionyl chloride / Reflux

With thionyl chloride; potassium carbonate; In acetone;

DOI:10.1016/j.bmcl.2012.01.101

Reference yield:

2-[4-(benzyloxy)benzyl]acetic acid (6547-53-1) → (2-benzyloxy-phenyl)-acetyl chloride (115439-34-4)

Guidance literature:

With thionyl chloride; Reflux;

DOI:10.1016/j.bmcl.2012.01.101

Reference yield:

(2-benzyloxy-phenyl)-acetyl chloride (115439-34-4) → (2-Benzyloxy-phenyl)-acetyl azide

Guidance literature:

With sodium azide; In water; acetone; at 0 - 5 ℃; for 0.5h;

DOI:10.1021/jm00099a003

upstream raw materials:

2-[4-(benzyloxy)benzyl]acetic acid

benzyl bromide

Downstream raw materials:

1-diazo-3-<2'-(benzyloxy)phenyl>propan-2-one

(S)-3-[2-(2-Benzyloxy-phenyl)-acetyl]-4-isopropyl-oxazolidin-2-one

(R)-3-[2-(2-Benzyloxy-phenyl)-acetyl]-4-isopropyl-oxazolidin-2-one

(R)-3-[(2R,3R)-3-(4-Benzyloxy-phenyl)-2-(2-benzyloxy-phenyl)-3-hydroxy-propionyl]-4-isopropyl-oxazolidin-2-one