(S)-3-(1H-Imidazol-4-yl)-2-((R)-4-morpholin-4-yl-2-naphthalen-1-ylmethyl-4-oxo-butyrylamino)-propionic acid methyl ester; compound with 2-hydroxy-benzoic acid

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Chemical Name:(S)-3-(1H-Imidazol-4-yl)-2-((R)-4-morpholin-4-yl-2-naphthalen-1-ylmethyl-4-oxo-butyrylamino)-propionic acid methyl ester; compound with 2-hydroxy-benzoic acid
CAS No.:124483-26-7
Molecular Formula:C₇H₆O₃*C₂₆H₃₀N₄O₅
Molecular Weight:616.671
Hs Code.:

(S)-3-(1H-Imidazol-4-yl)-2-((R)-4-morpholin-4-yl-2-naphthalen-1-ylmethyl-4-oxo-butyrylamino)-propionic acid methyl ester; compound with 2-hydroxy-benzoic acid

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Chemical Property of (S)-3-(1H-Imidazol-4-yl)-2-((R)-4-morpholin-4-yl-2-naphthalen-1-ylmethyl-4-oxo-butyrylamino)-propionic acid methyl ester; compound with 2-hydroxy-benzoic acid

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Technology Process of (S)-3-(1H-Imidazol-4-yl)-2-((R)-4-morpholin-4-yl-2-naphthalen-1-ylmethyl-4-oxo-butyrylamino)-propionic acid methyl ester; compound with 2-hydroxy-benzoic acid

There total 6 articles about (S)-3-(1H-Imidazol-4-yl)-2-((R)-4-morpholin-4-yl-2-naphthalen-1-ylmethyl-4-oxo-butyrylamino)-propionic acid methyl ester; compound with 2-hydroxy-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.2%

: 106868-65-9,113724-12-2,113724-13-3,129783-55-7
N-<(2RS)-3-(Morpholinocarbonyl)-2-(1-naphthylmethyl)propionyl>-L-histidine methyl ester

: 69-72-7,25496-36-0,8052-31-1
salicylic acid

: 124483-26-7
(S)-3-(1H-Imidazol-4-yl)-2-((R)-4-morpholin-4-yl-2-naphthalen-1-ylmethyl-4-oxo-butyrylamino)-propionic acid methyl ester; compound with 2-hydroxy-benzoic acid

Guidance literature:: DOI:10.1021/jo00292a052

Reference yield:

: 103632-75-3
2-(1-Naphthylmethylidene)succinic anhydride

: 124483-26-7
(S)-3-(1H-Imidazol-4-yl)-2-((R)-4-morpholin-4-yl-2-naphthalen-1-ylmethyl-4-oxo-butyrylamino)-propionic acid methyl ester; compound with 2-hydroxy-benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / ethyl acetate

2: 97.5 percent / H₂ / 10percent Pd/C / methanol / 760 Torr

3: 83 percent / triethylamine, N-hydroxy-5-norbornene-2,3-dicarboximide (HONB), 1,3-dicyclohexylcarbodiimide (DCC) / acetonitrile / 1.)0 deg C, 2 h, 2.)25 deg C

4: 36.2 percent

With N-hydroxy-5-norbornene-2,3-dicarboximide; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethyl acetate; acetonitrile;
DOI:10.1021/jo00292a052

Reference yield:

: 125702-08-1
2-(1-Naphthylmethylidene)succinic Acid

: 124483-26-7
(S)-3-(1H-Imidazol-4-yl)-2-((R)-4-morpholin-4-yl-2-naphthalen-1-ylmethyl-4-oxo-butyrylamino)-propionic acid methyl ester; compound with 2-hydroxy-benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / SOCl₂ / CH₂Cl₂ / 3 h / Heating

2: 84 percent / ethyl acetate

3: 97.5 percent / H₂ / 10percent Pd/C / methanol / 760 Torr

4: 83 percent / triethylamine, N-hydroxy-5-norbornene-2,3-dicarboximide (HONB), 1,3-dicyclohexylcarbodiimide (DCC) / acetonitrile / 1.)0 deg C, 2 h, 2.)25 deg C

5: 36.2 percent

With thionyl chloride; N-hydroxy-5-norbornene-2,3-dicarboximide; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/jo00292a052