(2S,4S)-4-Benzyloxy-1-{2-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-2-methyl-3-((S)-2-phenyl-[1,3]dioxan-4-yl)-propyl]-[1,3]dithian-2-yl}-6-(4-methoxy-phenoxy)-hexan-2-ol

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Chemical Name:(2S,4S)-4-Benzyloxy-1-{2-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-2-methyl-3-((S)-2-phenyl-[1,3]dioxan-4-yl)-propyl]-[1,3]dithian-2-yl}-6-(4-methoxy-phenoxy)-hexan-2-ol
CAS No.:209340-38-5
Molecular Formula:C₄₄H₆₄O₇S₂Si
Molecular Weight:797.205
Hs Code.:

(2S,4S)-4-Benzyloxy-1-{2-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-2-methyl-3-((S)-2-phenyl-[1,3]dioxan-4-yl)-propyl]-[1,3]dithian-2-yl}-6-(4-methoxy-phenoxy)-hexan-2-ol

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Chemical Property of (2S,4S)-4-Benzyloxy-1-{2-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-2-methyl-3-((S)-2-phenyl-[1,3]dioxan-4-yl)-propyl]-[1,3]dithian-2-yl}-6-(4-methoxy-phenoxy)-hexan-2-ol

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Technology Process of (2S,4S)-4-Benzyloxy-1-{2-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-2-methyl-3-((S)-2-phenyl-[1,3]dioxan-4-yl)-propyl]-[1,3]dithian-2-yl}-6-(4-methoxy-phenoxy)-hexan-2-ol

There total 11 articles about (2S,4S)-4-Benzyloxy-1-{2-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-2-methyl-3-((S)-2-phenyl-[1,3]dioxan-4-yl)-propyl]-[1,3]dithian-2-yl}-6-(4-methoxy-phenoxy)-hexan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 117285-92-4
(R)-3-Benzyloxy-4-(S)-oxiranyl-butyric acid benzyl ester

: 209340-38-5
(2S,4S)-4-Benzyloxy-1-{2-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-2-methyl-3-((S)-2-phenyl-[1,3]dioxan-4-yl)-propyl]-[1,3]dithian-2-yl}-6-(4-methoxy-phenoxy)-hexan-2-ol

Guidance literature:: Multi-step reaction with 10 steps

1: DIBALH / toluene / 0.5 h / -78 °C

2: NaBH₄ / methanol / 0.5 h / 0 °C

3: 96 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

4: 1.) n-BuLi / 1.) HMPA, THF, -20 deg C, 2 h; 2.) HMPA, THF, -20 deg C, 2 h

5: IBX / dimethylsulfoxide; tetrahydrofuran / 5 h / Ambient temperature

6: tetrahydrofuran; diethyl ether / 1 h / Ambient temperature

7: 64 percent / BCl₃, 1,3-propanedithiol / CH₂Cl₂ / 1 h / Ambient temperature

8: 63 percent / PPTS / CH₂Cl₂ / 48 h / Ambient temperature

9: 98 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / Ambient temperature

10: 1.) n-BuLi / 1.) HMPA, THF, -20 deg C, 1 h; 2.) HMPA, THF, -20 deg C, 0.5 h

With 2,6-dimethylpyridine; 1.3-propanedithiol; sodium tetrahydroborate; n-butyllithium; pyridinium p-toluenesulfonate; boron trichloride; diisobutylaluminium hydride; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1016/S0040-4039(98)00619-4

Reference yield:

: 134978-28-2
(S)-3-Benzyloxy-4-(S)-oxiranyl-butan-1-ol

: 209340-38-5
(2S,4S)-4-Benzyloxy-1-{2-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-2-methyl-3-((S)-2-phenyl-[1,3]dioxan-4-yl)-propyl]-[1,3]dithian-2-yl}-6-(4-methoxy-phenoxy)-hexan-2-ol

Guidance literature:: Multi-step reaction with 8 steps

1: 96 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

2: 1.) n-BuLi / 1.) HMPA, THF, -20 deg C, 2 h; 2.) HMPA, THF, -20 deg C, 2 h

3: IBX / dimethylsulfoxide; tetrahydrofuran / 5 h / Ambient temperature

4: tetrahydrofuran; diethyl ether / 1 h / Ambient temperature

5: 64 percent / BCl₃, 1,3-propanedithiol / CH₂Cl₂ / 1 h / Ambient temperature

6: 63 percent / PPTS / CH₂Cl₂ / 48 h / Ambient temperature

7: 98 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / Ambient temperature

8: 1.) n-BuLi / 1.) HMPA, THF, -20 deg C, 1 h; 2.) HMPA, THF, -20 deg C, 0.5 h

With 2,6-dimethylpyridine; 1.3-propanedithiol; n-butyllithium; pyridinium p-toluenesulfonate; boron trichloride; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(98)00619-4

Reference yield:

: (R)-3-Benzyloxy-4-(S)-oxiranyl-butyric acid

: 209340-38-5
(2S,4S)-4-Benzyloxy-1-{2-[(S)-2-(tert-butyl-dimethyl-silanyloxy)-2-methyl-3-((S)-2-phenyl-[1,3]dioxan-4-yl)-propyl]-[1,3]dithian-2-yl}-6-(4-methoxy-phenoxy)-hexan-2-ol

Guidance literature:: Multi-step reaction with 9 steps

1: NaBH₄ / methanol / 0.5 h / 0 °C

2: 96 percent / Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

3: 1.) n-BuLi / 1.) HMPA, THF, -20 deg C, 2 h; 2.) HMPA, THF, -20 deg C, 2 h

4: IBX / dimethylsulfoxide; tetrahydrofuran / 5 h / Ambient temperature

5: tetrahydrofuran; diethyl ether / 1 h / Ambient temperature

6: 64 percent / BCl₃, 1,3-propanedithiol / CH₂Cl₂ / 1 h / Ambient temperature

7: 63 percent / PPTS / CH₂Cl₂ / 48 h / Ambient temperature

8: 98 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / Ambient temperature

9: 1.) n-BuLi / 1.) HMPA, THF, -20 deg C, 1 h; 2.) HMPA, THF, -20 deg C, 0.5 h

With 2,6-dimethylpyridine; 1.3-propanedithiol; sodium tetrahydroborate; n-butyllithium; pyridinium p-toluenesulfonate; boron trichloride; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(98)00619-4