(S)-2-amino-N,4-dimethylpentanamide hydrochloride

Base Information

• Chemical Name: (S)-2-amino-N,4-dimethylpentanamide hydrochloride
• CAS No.: 99145-71-8
• Molecular Formula: C₇H₁₆N₂O*ClH
• Molecular Weight: 180.678

Synonyms:

Chemical Property of (S)-2-amino-N,4-dimethylpentanamide hydrochloride

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

H-L-Leu-NHMe*HCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-amino-N,4-dimethylpentanamide hydrochloride

There total 2 articles about (S)-2-amino-N,4-dimethylpentanamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Nα-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-leucinamide (67308-27-4) → (S)-2-amino-N,4-dimethylpentanamide hydrochloride (99145-71-8)

Guidance literature:

With hydrogenchloride; In ethyl acetate;

DOI:10.1248/cpb.50.239

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → (S)-2-amino-N,4-dimethylpentanamide hydrochloride (99145-71-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

2: hydrogenchloride / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2014.11.056

Reference yield: 33.0%

(S)-2-amino-N,4-dimethylpentanamide hydrochloride (99145-71-8) + Cbz-ΔGlu(OMe)-OMe → Cbz-ΔGlu(OMe)-Leu-NHMe

Guidance literature:

With McIlvaine buffer pH 8.0; 2-hydroxyethanethiol; at 35 ℃; for 24h; papain;

DOI:10.1246/bcsj.66.2048

upstream raw materials:

N^α-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-leucinamide

N-tert-butoxycarbonyl-L-leucine

Downstream raw materials:

Nα-(t-butoxycarbonyl)-O-(diphenylphosphono)serylleucine N-methylamide

(S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N,4-dimethylpentanamide lithium

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