Technology Process of 2-chloromethyl-7-phenoxy-6-sulfamoyl-2,3-dihydro-1,4-benzodioxin
There total 6 articles about 2-chloromethyl-7-phenoxy-6-sulfamoyl-2,3-dihydro-1,4-benzodioxin which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
pyridine; thionyl chloride;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 81.7 percent / NaH / dimethylformamide / 1.) r.t., 30 min, 2.) 80 deg C, 3 h
2: 75.3 percent / NaOH / Cu powder / 4 h / 150 - 170 °C
3: 91.1 percent / metallic iron, conc. HCl / methanol / 10 h / Heating
4: 1.) NaNO2, AcOH, conc. HCl, 2.) CuCl2*2H2O, 33percent SO2-AcOH / 1.) H2O, -15 - -5 deg C, 35 min, 2.) H2O, 33 deg C, 50 min
5: conc. NH4OH / acetone / 0.5 h / Heating
6: 76 percent / thionyl chloride, pyridine / Ambient temperature
With
pyridine; hydrogenchloride; ammonium hydroxide; sodium hydroxide; thionyl chloride; sulfur dioxide; iron; sodium hydride; acetic acid; sodium nitrite;
copper;
In
methanol; N,N-dimethyl-formamide; acetone;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 75.3 percent / NaOH / Cu powder / 4 h / 150 - 170 °C
2: 91.1 percent / metallic iron, conc. HCl / methanol / 10 h / Heating
3: 1.) NaNO2, AcOH, conc. HCl, 2.) CuCl2*2H2O, 33percent SO2-AcOH / 1.) H2O, -15 - -5 deg C, 35 min, 2.) H2O, 33 deg C, 50 min
4: conc. NH4OH / acetone / 0.5 h / Heating
5: 76 percent / thionyl chloride, pyridine / Ambient temperature
With
pyridine; hydrogenchloride; ammonium hydroxide; sodium hydroxide; thionyl chloride; sulfur dioxide; iron; acetic acid; sodium nitrite;
copper;
In
methanol; acetone;
