6-Methoxy-5-methylnicotinonitrile

Base Information

• Chemical Name: 6-Methoxy-5-methylnicotinonitrile
• CAS No.: 1033439-60-9
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.164
• DSSTox Substance ID: DTXSID00697095
• Wikidata: Q82626915
• Mol file: 1033439-60-9.mol

Synonyms:6-Methoxy-5-methylnicotinonitrile;1033439-60-9;6-METHOXY-5-METHYL-3-PYRIDINECARBONITRILE;6-METHOXY-5-METHYLPYRIDINE-3-CARBONITRILE;2-METHOXY-3-METHYL-5-CYANOPYRIDINE;SCHEMBL2470931;DTXSID00697095;IIOOEESKNIJLGN-UHFFFAOYSA-N;MFCD12024298;5-cyano-2-methoxy-3-methyl-pyridine;AKOS022174388;AB65209;CS-0195670

Chemical Property of 6-Methoxy-5-methylnicotinonitrile

Chemical Property:

• Storage Temp.: 2-8°C
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 148.063662883
• Heavy Atom Count: 11
• Complexity: 172

Purity/Quality:

99% ^*data from raw suppliers

6-Methoxy-5-methyl-3-pyridinecarbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=CN=C1OC)C#N

Technology Process of 6-Methoxy-5-methylnicotinonitrile

There total 7 articles about 6-Methoxy-5-methylnicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-bromo-2-methoxy-3-methylpyridine (760207-87-2) + copper(l) cyanide → 5-cyano-2-methoxy-3-methylpyridine (1033439-60-9)

Guidance literature:

In N,N-dimethyl-formamide; at 130 ℃; for 28h; Inert atmosphere;

Reference yield: 57.0%

→ 5-cyano-2-methoxy-3-methylpyridine (1033439-60-9)

Guidance literature:

Reference yield:

5-bromo-2-methoxy-3-methylpyridine (760207-87-2) + copper(I) cyanide (544-92-3) → 5-cyano-2-methoxy-3-methylpyridine (1033439-60-9)

Guidance literature:

In N,N-dimethyl-formamide; for 28h; Heating / reflux;

upstream raw materials:

5-bromo-2-methoxy-3-methylpyridine

copper(I) cyanide

5-bromo-3-methyl-pyridin-2-ylamine

5-bromo-3-methylpyridin-2(1H)-one

Downstream raw materials:

C₈H₁₂N₂O*ClH

C₃₁H₂₄F₃N₅O₅

C₂₄H₂₂F₃N₅O₄

C₂₄H₂₄F₃N₅O₂

Refernces

• 1、 Tremblay, Martin,Bonneau, Pierre,Bousquet, Yves,Deroy, Patrick,Duan, Jianmin,Duplessis, Martin,Gagnon, Alexandre,Garneau, Michel,Goudreau, Nathalie,Guse, Ingrid,Hucke, Oliver,Kawai, Stephen H.,Lemke, Christopher T.,Mason, Stephen W.,Simoneau, Bruno,Surprenant, Simon,Titolo, Steve,Yoakim, Christiane. "Inhibition of HIV-1 capsid assembly: Optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol- 1-yl)-1H-benzimidazole scaffold". . p. 7512 - 7517. Retrieved 2013/02/23.
• 2、 -. "INHIBITORS OF HIV REPLICATION". Page/Page column 39; 40. . Retrieved 2008/12/06.