L-Glutamic acid, N-[4-[[[(6R)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl] methyl]amino]benzoyl]-, calcium salt (1:1)

Base Information

• Chemical Name: L-Glutamic acid, N-[4-[[[(6R)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl] methyl]amino]benzoyl]-, calcium salt (1:1)
• CAS No.: 115940-48-2
• Molecular Formula: C₂₀H₂₁N₇O₇*Ca
• Molecular Weight: 511.507
• Mol file: 115940-48-2.mol

Synonyms:

Chemical Property of L-Glutamic acid, N-[4-[[[(6R)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl] methyl]amino]benzoyl]-, calcium salt (1:1)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Glutamic acid, N-[4-[[[(6R)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl] methyl]amino]benzoyl]-, calcium salt (1:1)

There total 5 articles about L-Glutamic acid, N-[4-[[[(6R)-2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl] methyl]amino]benzoyl]-, calcium salt (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

<5,10-Metheno-5,6,7,8-tetrahydrofolsaeure>(1+)Cl(1-) → calcium folinate (1492-18-8,67005-79-2,80433-71-2,115940-48-2,137693-89-1,137693-90-4,137693-91-5,138457-37-1,138457-38-2)

Guidance literature:

With sodium hydroxide; phosphate buffer pH₇; for 5h; Heating;

Reference yield: 48.0%

(6R)-5,10-methylylidenetetrahydrofolic acid chloride (65981-90-0) → (6S)-5-formyltetrahydrofolic acid calcium salt (1492-18-8,67005-79-2,80433-71-2,115940-48-2,137693-89-1,137693-90-4,137693-91-5,138457-37-1,138457-38-2)

Guidance literature:

With water; calcium chloride; Heating;

DOI:10.1016/S0040-4020(01)87409-3

Reference yield: 42.7%

(6S,S)-5,6,7,8-tetrahydrofolic acid (135-16-0,15582-28-2,29347-89-5,71963-69-4,74708-38-6) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → calcium 5-methyl-(6S)-tetrahydrofolic acid 6(S)-5-methyl tetrahydrofolate + (6S)-5-formyltetrahydrofolic acid calcium salt (1492-18-8,67005-79-2,80433-71-2,115940-48-2,137693-89-1,137693-90-4,137693-91-5,138457-37-1,138457-38-2)

Guidance literature:

(6S,S)-5,6,7,8-tetrahydrofolic acid; formaldehyd; With sodium hydroxide; In water; for 0.5h; pH=9;

With potassium borohydride; In water; at 15 ℃; for 4h; pH=9;

DOI:10.1007/s11164-012-0751-2

upstream raw materials:

(6R)-5,10-methylylidenetetrahydrofolic acid chloride

(6S,S)-5,6,7,8-tetrahydrofolic acid

formaldehyd