misoprostol

Base Information

Chemical Name:misoprostol
CAS No.:58682-80-7
Molecular Formula:C₂₂H₃₈O₅
Molecular Weight:382.541
Hs Code.:

Synonyms:

Suppliers and Price of misoprostol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of misoprostol

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of misoprostol

There total 21 articles about misoprostol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 848849-83-2
misoprostol

: 58682-80-7,58682-81-8,58717-36-5,58717-37-6,59122-46-2,59122-48-4,59122-50-8,59122-51-9,138284-96-5,59122-49-5
misoprostol

Guidance literature:

Reference yield:

: 31752-99-5
(-)-Corey lactone 5-(4-phenylbenzoate)

: 58682-80-7,58682-81-8,58717-36-5,58717-37-6,59122-46-2,59122-48-4,59122-50-8,59122-51-9,138284-96-5,59122-49-5
misoprostol

Guidance literature:: Multi-step reaction with 13 steps

1: 94 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

2: 65 percent / CH₃ONa / methanol / 1.33 h / Ambient temperature

3: 90 percent / PPTS / 1,2-dichloro-ethane / 2 h / Ambient temperature

4: 94 percent / DIBAL / toluene / 0.75 h / -70 °C

5: 1.) t-BuOK / 1.) THF, 5 deg C, 15 min, 2.) THF, 5 deg C, 60 min

6: K₂CO₃ / acetone / 15 h / Ambient temperature

7: 90 percent / 4-dimethylpyridine, pyridine / 1.) diminished temp., 10 min, 2.) r.t., 60 min

8: 93 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 10 °C

9: 96 percent / H₂ / 10percent Pd/C / ethyl acetate / Ambient temperature

10: 1.) DMSO, oxalyl chloride, 2.) Et₃N / 1.) CH₂Cl₂, -75 deg C, 1 h, 2.) -75 deg C to r.t.

12: 85 percent / Collins reagent / CH₂Cl₂ / 2 h / Ambient temperature

13: HCl / tetrahydrofuran / 0.5 h / Ambient temperature

With pyridine; 1H-imidazole; hydrogenchloride; 4-dimethylpyridine; oxalyl dichloride; Collins oxidation agent; potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; sodium methylate; pyridinium p-toluenesulfonate; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1135/cccc19971325

Reference yield:

: 65025-95-8
(3aR,4S,5R,6aS)-4-({[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl)-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-one

: 58682-80-7,58682-81-8,58717-36-5,58717-37-6,59122-46-2,59122-48-4,59122-50-8,59122-51-9,138284-96-5,59122-49-5
misoprostol

Guidance literature:: Multi-step reaction with 10 steps

1: 94 percent / DIBAL / toluene / 0.75 h / -70 °C

2: 1.) t-BuOK / 1.) THF, 5 deg C, 15 min, 2.) THF, 5 deg C, 60 min

3: K₂CO₃ / acetone / 15 h / Ambient temperature

4: 90 percent / 4-dimethylpyridine, pyridine / 1.) diminished temp., 10 min, 2.) r.t., 60 min

5: 93 percent / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 10 °C

6: 96 percent / H₂ / 10percent Pd/C / ethyl acetate / Ambient temperature

7: 1.) DMSO, oxalyl chloride, 2.) Et₃N / 1.) CH₂Cl₂, -75 deg C, 1 h, 2.) -75 deg C to r.t.

9: 85 percent / Collins reagent / CH₂Cl₂ / 2 h / Ambient temperature

10: HCl / tetrahydrofuran / 0.5 h / Ambient temperature

With pyridine; hydrogenchloride; 4-dimethylpyridine; oxalyl dichloride; Collins oxidation agent; potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; acetone; toluene;
DOI:10.1135/cccc19971325