1-Azaspiro[2.5]octane

Base Information

• Chemical Name: 1-Azaspiro[2.5]octane
• CAS No.: 185-69-3
• Molecular Formula: C7H13 N
• Molecular Weight: 111.187
• Hs Code.: 2933990090
• Mol file: 185-69-3.mol

Synonyms:NSC 145089;Spirocyclohexylethylenimine

Chemical Property of 1-Azaspiro[2.5]octane

Chemical Property:

• Vapor Pressure: 1.67mmHg at 25°C
• Boiling Point: 167.8°C at 760 mmHg
• Flash Point: 46.8°C
• PSA: 21.94000
• Density: 0.96g/cm³
• LogP: 1.62130

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Azaspiro[2.5]octane

There total 4 articles about 1-Azaspiro[2.5]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1-aminocyclohexyl)methanol (4313-56-8) → 1-aza-spiro[2.5]octane (185-69-3)

Guidance literature:

Multi-step reaction with 2 steps

1: water; H₂SO₄ / unter vermindertem Druck

2: aq. NaOH solution

With sodium hydroxide; sulfuric acid; water;

DOI:10.1021/jo01086a021

Reference yield:

sulfuric acid mono-(1-amino-cyclohexylmethyl ester) (118836-07-0) → 1-aza-spiro[2.5]octane (185-69-3)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/jo01086a021

Reference yield:

1-aminocyclohexane carboxylic acid (2756-85-6) → 1-aza-spiro[2.5]octane (185-69-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride

2.1: chlorosulfonic acid

2.2: Reflux

With chlorosulfonic acid; lithium aluminium tetrahydride;

DOI:10.1021/acs.joc.5b01429

upstream raw materials:

sulfuric acid mono-(1-amino-cyclohexylmethyl ester)

(1-aminocyclohexyl)methanol

1-aminocyclohexane carboxylic acid

Downstream raw materials:

1-acetyl-1-aza-spiro[2.5]octane

N-cyclohex-1-enylmethyl-acetamide

1-ethyl-1-aza-spiro[2.5]octane

1-aza-spiro[2.5]octane-1-carbothioic acid anilide