4313-56-8

Usage

Uses

Used in Pharmaceutical Industry:
(1-aminocyclohexyl)methanol is used as a synthetic building block for the creation of Fsp3-rich, bis-spirocyclic-based compound libraries. These compound libraries are essential in the development of novel pharmaceuticals, particularly those targeting complex diseases and conditions. The unique structural features of ACHM enable the formation of diverse and biologically active molecules, contributing to the advancement of drug discovery and therapeutic innovation.
Used in Chemical Research:
In the field of chemical research, (1-aminocyclohexyl)methanol serves as a key intermediate for the synthesis of various complex organic molecules. Its unique structure allows for further functionalization and modification, making it a valuable tool in the development of new chemical entities with potential applications in various industries, including materials science, agrochemicals, and specialty chemicals.
Used in Material Science:
(1-aminocyclohexyl)methanol is used as a precursor in the development of novel materials with specific properties, such as improved mechanical strength, thermal stability, or chemical resistance. Its incorporation into polymeric structures can lead to the creation of advanced materials with tailored properties for use in various applications, including automotive, aerospace, and electronics industries.

Upstream product

• 3719-52-6 (1-nitrocyclohexyl)methanol 
• 1664-34-2 1-amino-1-cyclohexanecarboxylic acid ethyl ester 
• 2756-85-6 1-aminocyclohexane carboxylic acid 
• 39692-17-6 1-amino-1-cyclohexane carboxylic acid hydrochloride 
• 1122-60-7 1-nitrocyclohexane 
• 285124-16-5 benzyl N-[(1-hydroxymethyl)cyclohexyl]carbamate 
• 4507-57-7 methyl 1-aminocyclohexanecarboxylate 
• 1125-02-6 1-cyano-1-formamidocyclohexane 

Downstream Products

• 4368-61-0 1-(dimethylamino)-1-cyclohexanecarbinol 
• 90204-86-7 N-(1-hydroxymethyl-cyclohexyl)-formamide 
• 118836-07-0 sulfuric acid mono-(1-amino-cyclohexylmethyl ester) 
• 100400-91-7 1-acetoxymethyl-1-acetylamino-cyclohexane 
• 101725-44-4 N₁,N₂-bis(1-(hydroxymethyl)cyclohexyl)oxalamide 
• 81467-34-7 3-oxa-1-azaspiro[4.5]decan-2-one 
• 111719-49-4 1-benzoyl-2-phenyl-3-oxa-1-aza-spiro[4.5]decane 
• 107055-54-9 1-benzoyl-3-oxa-1-aza-spiro[4.5]decane 
• 13892-96-1 1-(bromomethyl)cyclohexylammonium bromide 
• 606970-66-5 N¹,N²-bis(1-(chloromethyl)cyclohexyl)oxalamide 
• 36306-69-1 C₇H₁₄ClN*ClH 
• 307523-50-8 C₁₉H₂₄NO⁽¹⁺⁾*Cl^(1-) 
• 285124-16-5 benzyl N-[(1-hydroxymethyl)cyclohexyl]carbamate 

Relevant academic research and scientific papers

CYCLIN-DEPENDENT KINASE INHIBITING COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS

This invention is in the area of cell cycle inhibiting compounds for the treatment of disorders involving abnormal cellular proliferation, and include selective CDK2 inhibitors for medical therapy and their pharmaceutically acceptable salts and compositions.

PROCESS FOR PRODUCING SUBSTITUTED AMINO ALCOHOLS

The present invention relates to a process for producing a compound of the formula (I) comprising at least the process step: a) reacting a compound of the formula (II) with hydrogen and water in the presence of at least one homogeneous transition metal catalyst TMC 1.

PYRIMIDINE-BASED ANTIPROLIFERATIVE AGENTS

This invention is in the area of pyrimidine-based compounds for the treatment of disorders involving abnormal cellular proliferation, including but not limited to tumors and cancers.

Design and Synthesis of Fsp3-Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

The exploration of innovative chemical space is a critical step in the early phases of drug discovery. Bis-spirocyclic frameworks occur in natural products and other biologically relevant metabolites and show attractive features, such as molecular compactness, structural complexity, and three-dimensional character. A concise approach to the synthesis of bis-spirocyclic-based compound libraries starting from readily available commercial reagents and robust chemical transformations has been developed. A number of novel bis-spirocyclic scaffold examples, as implemented in the European Lead Factory project, is presented.

TRICYCLIC LACTAMS FOR USE IN THE PROTECTION OF NORMAL CELLS DURING CHEMOTHERAPY

This invention is in the area of tricyclic lactam compounds, compositions and methods of protecting healthy cells, and in particular hematopoietic stem and progenitor cells (HSPC) as well as renal cells, from damage associated with DNA damaging chemotherapeutic agents. In one aspect, protection of healthy cells is disclosed using compounds that act as cyclin-dependent kinase 4/6 (CDK 4/6) inhibitors when administered to subjects undergoing DNA damaging chemotherapeutic regimens for the treatment of proliferative disorders.

Modular, One-Pot, Sequential Aziridine Ring Opening-SNAr Strategy to 7-, 10-, and 11-Membered Benzo-Fused Sultams

The generation of common and stereochemically rich medium-sized benzo-fused sultams via complementary pairing of heretofore-unknown (o-fluoroaryl)sulfonyl aziridine building blocks with an array of amino alcohols/amines in a modular one-pot, sequential protocol using an aziridine ring opening and intramolecular nucleophilic aromatic substitution is reported. The strategy employs a variety of amino alcohols/amines and proceeds with 6 + 4/6 + 5 and 6 + 1 cycloetherification pathways in a highly chemo- and regioselective fashion to obtain skeletally and structurally diverse, polycyclic, 10- to 11- and 7-membered benzo-fused sultams for broad-scale screening.

HETEROCYCLIC BENZIMIDAZOLES AS TRPM8 MODULATORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula (I) as follows: wherein W1, W2, W3, R1/s

NITRATED HYDROCARBONS, DERIVATIVES, AND PROCESSES FOR THEIR MANUFACTURE

Provided is a process for the formation of nitrated compounds by the nitration of hydrocarbon compounds with dilute nitric acid. Also provided are processes for preparing industrially useful downstream derivatives of the nitrated compounds, as well as novel nitrated compounds and derivatives, and methods of using the derivatives in various applications.

Synthesis and use of achiral oxazolidine-2-thiones in selective preparation of trans 2,5-disubstituted tetrahydrofurans

The use of achiral N-acetyloxazolidine-2-thiones in the C-glycosylation of lactol acetates has allowed us to prepare with high diastereoselectivity the expected trans 2,5-disubstituted tetrahydrofurans. A study based on the role of the steric hindrance of the N-acetyloxazolidine-2-thiones is reported. Wiley-VCH Verlag GmbH & Co. KGaA, 2009.

AMINOALCOHOL AND BIOCIDE COMPOSITIONS FOR AQUEOUS BASED SYSTEMS

Biocidal compositions and their use in aqueous media, such as metalworking fluids, the compositions comprising a biocidal agent; and a non-biocidal primary amino alcohol compound of the formula (I): wherein R1, R2, R3, R4, and R5 are as defined herein.