Technology Process of 3-Oxo-3-((1Z,4Z,9Z,15Z)-7,12,18-triethyl-3,13,17-trimethyl-porphyrin-2-yl)-propionic acid benzyl ester
There total 15 articles about 3-Oxo-3-((1Z,4Z,9Z,15Z)-7,12,18-triethyl-3,13,17-trimethyl-porphyrin-2-yl)-propionic acid benzyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 92 percent / acetic acid / 1 h / 100 °C
2: H2 / Pd
3: 1.) trifluoroacetic acid / 1.) RT, 10 min, 2.) 0 deg C, 10 min
4: 1.) trifluoroacetic acid / 1.) RT, 15 min, 2.) methanol, RT, 40 min
6: pyridine, aq. NaOH / 0.75 h / Heating
7: oxalyl chloride / CH2Cl2 / 1 h / Heating
8: tetrahydrofuran / 0.08 h / Heating
With
pyridine; sodium hydroxide; oxalyl dichloride; hydrogen; acetic acid; trifluoroacetic acid;
palladium;
In
tetrahydrofuran; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 74 percent / tin(II) chloride dihydrate / 1.) 55 deg C, 5 min, 2.) RT, 1 h
2: 1.) sodium borohydride, 2.) BF3*Et2O / 1.) THF, 5 deg C, 2.) THF, 1 h
3: 60 percent / acetic acid, acetic anhydride / 2.5 h / Ambient temperature
4: 92 percent / acetic acid / 1 h / 100 °C
5: H2 / Pd
6: 1.) trifluoroacetic acid / 1.) RT, 10 min, 2.) 0 deg C, 10 min
7: 1.) trifluoroacetic acid / 1.) RT, 15 min, 2.) methanol, RT, 40 min
9: pyridine, aq. NaOH / 0.75 h / Heating
10: oxalyl chloride / CH2Cl2 / 1 h / Heating
11: tetrahydrofuran / 0.08 h / Heating
With
pyridine; sodium hydroxide; sodium tetrahydroborate; oxalyl dichloride; boron trifluoride diethyl etherate; hydrogen; acetic anhydride; acetic acid; trifluoroacetic acid; tin(ll) chloride;
palladium;
In
tetrahydrofuran; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 60 percent / acetic acid, acetic anhydride / 2.5 h / Ambient temperature
2: 92 percent / acetic acid / 1 h / 100 °C
3: H2 / Pd
4: 1.) trifluoroacetic acid / 1.) RT, 10 min, 2.) 0 deg C, 10 min
5: 1.) trifluoroacetic acid / 1.) RT, 15 min, 2.) methanol, RT, 40 min
7: pyridine, aq. NaOH / 0.75 h / Heating
8: oxalyl chloride / CH2Cl2 / 1 h / Heating
9: tetrahydrofuran / 0.08 h / Heating
With
pyridine; sodium hydroxide; oxalyl dichloride; hydrogen; acetic anhydride; acetic acid; trifluoroacetic acid;
palladium;
In
tetrahydrofuran; dichloromethane;
