1H-Pyrrole-3-carboxylicacid,2,4-dimethyl-,methylester(9CI)

Base Information

• Chemical Name: 1H-Pyrrole-3-carboxylicacid,2,4-dimethyl-,methylester(9CI)
• CAS No.: 52459-90-2
• Molecular Formula: C8H11 N O2
• Molecular Weight: 153.18
• Hs Code.: 2933990090
• Mol file: 52459-90-2.mol

Synonyms:Pyrrole-3-carboxylicacid, 2,4-dimethyl-, methyl ester (7CI); Methyl2,4-dimethyl-3-pyrrolecarboxylate

Chemical Property of 1H-Pyrrole-3-carboxylicacid,2,4-dimethyl-,methylester(9CI)

Chemical Property:

• Vapor Pressure: 0.00471mmHg at 25°C
• Boiling Point: 276.7°Cat760mmHg
• Flash Point: 121.2°C
• PSA: 42.09000
• Density: 1.108g/cm³
• LogP: 1.41810

Purity/Quality:

97% ^*data from raw suppliers

methyl2,4-dimethyl-1H-pyrrole-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrole-3-carboxylicacid,2,4-dimethyl-,methylester(9CI)

There total 19 articles about 1H-Pyrrole-3-carboxylicacid,2,4-dimethyl-,methylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

methyl 5-acetyl-2,4-dimethyl-1H-pyrrole-3-carboxylate (62264-99-7) → methyl 2,4-dimethyl-1H-pyrrole 3-carboxylate (52459-90-2)

Guidance literature:

With ethylene glycol; perchloric acid; In benzene; for 0.5h; Heating; other diols; TsOH;

DOI:10.1021/jo00189a002

Reference yield: 51.0%

methyl 5-acetyl-2,4-dimethyl-1H-pyrrole-3-carboxylate (62264-99-7) → methyl 2,4-dimethyl-1H-pyrrole 3-carboxylate (52459-90-2) + 4-benzoyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethyl ester (90433-74-2)

Guidance literature:

With ethandithiol; toluene-4-sulfonic acid; In benzene; for 18h; Heating; other times;

DOI:10.1021/jo00189a002

Reference yield: 44.0%

2,4-Dimethyl-1-trimethylsilanyl-2-trimethylsilanyloxy-2,5-dihydro-1H-pyrrole-3-carboxylic acid methyl ester → methyl 2,4-dimethyl-1H-pyrrole 3-carboxylate (52459-90-2)

Guidance literature:

With silicic acid;

DOI:10.1016/S0040-4039(00)96255-5

upstream raw materials:

methyl 5-(2-methyl-1,3-dithiolan-2-yl)-1,2,4-trimethyl-1H-pyrrole-3-carboxylate

2-methyl-1,3-dithiolan-2-yl perchlorate

2-methyl-2,4-pentanediol

methyl 5-acetyl-2,4-dimethyl-1H-pyrrole-3-carboxylate

Downstream raw materials:

benzyl 3-ethyl-4'-methoxycarbonyl-4,3',5'-trimethyl-2,2'-dipyrrylmethane-5-carboxylate

benzyl 3-ethyl-4'-methoxycarbonyl-3',5'-dimethyl-2,2'-dipyrrylmethane-5-carboxylate

3-Oxo-3-((1Z,4Z,9Z,15Z)-7,12,18-triethyl-3,13,17-trimethyl-porphyrin-2-yl)-propionic acid benzyl ester

benzyl 3,8,17-triethyl-2,12,18-trimethyl-13,15-(13'-oxo)ethanoporphyrin-15'-carboxylate