(S)-2-[2-((S)-3-Amino-2-hydroxy-4-phenyl-butyrylamino)-acetylamino]-4-methyl-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide; hydrochloride

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Chemical Name:(S)-2-[2-((S)-3-Amino-2-hydroxy-4-phenyl-butyrylamino)-acetylamino]-4-methyl-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide; hydrochloride
CAS No.:136138-79-9
Molecular Formula:C₂₃H₃₇N₅O₅S*ClH
Molecular Weight:532.104
Hs Code.:

(S)-2-[2-((S)-3-Amino-2-hydroxy-4-phenyl-butyrylamino)-acetylamino]-4-methyl-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide; hydrochloride

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Chemical Property of (S)-2-[2-((S)-3-Amino-2-hydroxy-4-phenyl-butyrylamino)-acetylamino]-4-methyl-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide; hydrochloride

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Technology Process of (S)-2-[2-((S)-3-Amino-2-hydroxy-4-phenyl-butyrylamino)-acetylamino]-4-methyl-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide; hydrochloride

There total 3 articles about (S)-2-[2-((S)-3-Amino-2-hydroxy-4-phenyl-butyrylamino)-acetylamino]-4-methyl-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 136138-78-8,136233-25-5
[(S)-1-Benzyl-2-({[(S)-1-((S)-1-carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-hydroxy-ethyl]-carbamic acid tert-butyl ester

: 136138-79-9,136314-61-9
(S)-2-[2-((S)-3-Amino-2-hydroxy-4-phenyl-butyrylamino)-acetylamino]-4-methyl-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide; hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; for 1h; Ambient temperature;
DOI:10.1016/0223-5234(91)90104-U

Reference yield:

: 1201292-56-9
(R,S)-α-hydroxy, (S)-β-amino, 4-phenylbutyric acid hydrochloride

: 136138-79-9,136314-61-9
(S)-2-[2-((S)-3-Amino-2-hydroxy-4-phenyl-butyrylamino)-acetylamino]-4-methyl-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 68.7 percent / aq. NaOH / dioxane / 1 h / 0 °C

2: 44 percent / 1-hydroxybenzotriazole (HOBt), N,N-dicyclohexylcarbodiimide (DCC), NMM / dimethylformamide / Ambient temperature

3: 0.34 g / HCl / ethyl acetate / 1 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In 1,4-dioxane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(91)90104-U

Reference yield:

: 191849-93-1
3(S)-(N-tert-butoxycarbonylamino)-2(R,S)-hydroxy-4-phenylbutyric acid

: 136138-79-9,136314-61-9
(S)-2-[2-((S)-3-Amino-2-hydroxy-4-phenyl-butyrylamino)-acetylamino]-4-methyl-pentanoic acid ((S)-1-carbamoyl-3-methylsulfanyl-propyl)-amide; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 44 percent / 1-hydroxybenzotriazole (HOBt), N,N-dicyclohexylcarbodiimide (DCC), NMM / dimethylformamide / Ambient temperature

2: 0.34 g / HCl / ethyl acetate / 1 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(91)90104-U