C₂₁H₂₂O₈

Base Information

• Chemical Name: C₂₁H₂₂O₈
• CAS No.: 111015-74-8
• Molecular Formula: C₂₁H₂₂O₈
• Molecular Weight: 402.401
• Mol file: 111015-74-8.mol

Synonyms:

Chemical Property of C₂₁H₂₂O₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₂O₈

There total 7 articles about C₂₁H₂₂O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

C27H30O8 (138223-77-5) → C21H22O8 (111015-74-8,138258-56-7) + C26H28O8 (138223-78-6)

Guidance literature:

With aluminium trichloride; sodium iodide; In acetonitrile; at 0 ℃; for 3h;

DOI:10.1016/0040-4039(91)80092-K

Reference yield: 22.0%

(1α,2β,3β,6β)-6-methoxy-4-cyclohexene-1,2,3-triol 2,3-dibenzoate (111015-72-6,124751-83-3) → DL-1,3-di-O-benzoyl-4-O-methyl-chiro-inositol (111015-74-8,138258-56-7) + DL-1,2-di-O-methyl-chiro-inositol (111015-73-7) + C21H22O8 (124647-07-0)

Guidance literature:

With tert.-butylhydroperoxide; osmium(VIII) oxide; tetraethylammonium acetate; In water; acetone; Yields of byproduct given; 1.) 0 deg C, 1.5 h, 2.) RT, 3 d.;

DOI:10.1016/S0040-4020(01)81025-5

Reference yield:

cis-1,2-dihydrocatechol (17793-95-2) → DL-1,3-di-O-benzoyl-4-O-methyl-chiro-inositol (111015-74-8,138258-56-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / DMAP / pyridine / 1.) 0 deg C, 2.5 h, 2.) RT

2: 73 percent / m-CPBA / CH₂Cl₂ / 22 h / Ambient temperature; pH 8 phosphate buffer

3: 100 percent / camphorsulfonic acid monohydrate / CHCl₃ / 22.5 h / Ambient temperature

4: osmium tetroxide, N-methylmorpholino-N-oxide / 2-methyl-propan-2-ol; tetrahydrofuran; H₂O / 84 h / Ambient temperature

With dmap; osmium(VIII) oxide; camphor-10-sulfonic acid; 4-methylmorpholine N-oxide; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; pyridine; dichloromethane; chloroform; water; tert-butyl alcohol;

DOI:10.1016/S0040-4020(01)81025-5

upstream raw materials:

(1α,2β,3β,6β)-6-methoxy-4-cyclohexene-1,2,3-triol 2,3-dibenzoate

cis-1,2-dihydrocatechol

cis-3,5-cyclohexadiene-1,2-diol dibenzoate

(1α,2α,5β,6Sb)-5,6-epoxy-3-cyclohexene-1,2-diol dibenzoate

Downstream raw materials:

4-O-methyl-myo-inositol