1-(5-chloro-2-hydroxy-4-methoxyphenyl)ethanone

Base Information

• Chemical Name: 1-(5-chloro-2-hydroxy-4-methoxyphenyl)ethanone
• CAS No.: 116265-99-7
• Molecular Formula: C9H9ClO3
• Molecular Weight: 200.622
• Mol file: 116265-99-7.mol

Synonyms:1-(5-Chloro-2-hydroxy-4-methoxy-phenyl)-ethanone;2-hydroxy-4-methoxy-5-chloro-acetophenone;1-(5-Chlor-2-hydroxy-4-methoxy-phenyl)-aethanon;

Chemical Property of 1-(5-chloro-2-hydroxy-4-methoxyphenyl)ethanone

Chemical Property:

• Melting Point: 154–155°C
• Boiling Point: 347.5±42.0 °C(Predicted)
• PKA: 9.36±0.23(Predicted)
• PSA: 46.53000
• Density: 1.291±0.06 g/cm3(Predicted)
• LogP: 2.25680

Purity/Quality:

95% ^*data from raw suppliers

1-(5-Chloro-2-hydroxy-4-methoxyphenyl)ethanone 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(5-chloro-2-hydroxy-4-methoxyphenyl)ethanone

There total 9 articles about 1-(5-chloro-2-hydroxy-4-methoxyphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-(5-chloro-2,4-dihydroxyphenyl)ethan-1-one (90110-32-0) + dimethyl sulfate (77-78-1) → 1-(5-chloro-2-hydroxy-4-methoxyphenyl)ethanone (116265-99-7)

Guidance literature:

With potassium carbonate; In acetone; at 0 - 20 ℃; for 48h; Concentration; Temperature;

Reference yield: 79.0%

1-chloro-2,4-dimethoxybenzene (7051-13-0) + acetyl chloride (75-36-5) → 1-(5-chloro-2-hydroxy-4-methoxyphenyl)ethanone (116265-99-7)

Guidance literature:

With aluminium trichloride; In 1,2-dichloro-ethane; 1) 0-5 deg C -> r.t., 2 h 2) reflux, 1h;

DOI:10.1248/cpb.39.1760

Reference yield: 73.0%

1-(2-hydroxy-4-methoxyphenyl)ethanone (552-41-0) → 1-(5-chloro-2-hydroxy-4-methoxyphenyl)ethanone (116265-99-7)

Guidance literature:

With N-chloro-succinimide; In N,N-dimethyl-formamide; at 20 - 60 ℃; for 48h;

upstream raw materials:

1-(2-hydroxy-4-methoxyphenyl)ethanone

1-(5-amino-2-hydroxy-4-methoxyphenyl)ethanone

1-chloro-2,4-dimethoxybenzene

acetyl chloride

Downstream raw materials:

(2-Acetyl-4-chloro-5-methoxy-phenoxy)-acetic acid ethyl ester