(R)-2-Hydroxyheptanenitrile

Base Information

• Chemical Name: (R)-2-Hydroxyheptanenitrile
• CAS No.: 116297-10-0
• Molecular Formula: C₇H₁₃NO
• Molecular Weight: 127.186
• Mol file: 116297-10-0.mol

Synonyms:2-hydroxyheptanonitrile;

Chemical Property of (R)-2-Hydroxyheptanenitrile

Chemical Property:

• PSA: 44.02000
• LogP: 1.45118

Purity/Quality:

99% ^*data from raw suppliers

(R)-2-HYDROXY HEPTANENITRILE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2-Hydroxyheptanenitrile

There total 14 articles about (R)-2-Hydroxyheptanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

hydrogen cyanide (74-90-8) + hexanal (66-25-1) → (S)-hexanal cyanohydrin (52358-06-2,95577-44-9,116297-10-0,106863-48-3)

Guidance literature:

With hydroxynitrile lyase from Hevea brasiliensis; In water; at 15 ℃; for 0.25h; pH 5.5;

DOI:10.1016/S0040-4020(98)00901-6

Reference yield: 82.0%

hydrogen cyanide (74-90-8) + hexanal (66-25-1) → (R)-2-hydroxyheptanenitrile (52358-06-2,95577-44-9,106863-48-3,116297-10-0)

Guidance literature:

With Prunus armeniaca hydroxynitrile lyase; In di-isopropyl ether; at 10 ℃; for 4h; pH=4; enantioselective reaction; Inert atmosphere; Enzymatic reaction;

DOI:10.1002/ejoc.201301365

Reference yield:

(+/-)-2-methyl-2-hydroxyhexanenitrile (4111-12-0) + hexanal (66-25-1) → n-hexan-2-one (591-78-6) + (S)-hexanal cyanohydrin (52358-06-2,95577-44-9,116297-10-0,106863-48-3) + (R)-2-hydroxyheptanenitrile (52358-06-2,95577-44-9,106863-48-3,116297-10-0) + (S)-2-hydroxy-2-methylhexanenitrile

Guidance literature:

With (R)-oxynitrilase in almond meal; tartrate buffer pH 5.4; In di-isopropyl ether; at 25 ℃; for 144h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1016/S0957-4166(97)00110-9

upstream raw materials:

hydrogen cyanide

hexanal

2-hydroxy-2-methylpropanenitrile

trimethylsilyl cyanide

Downstream raw materials:

(S)-2-(tert-butyldiphenylsilyloxy)heptanal

[(5S,6R)-5-(methoxymethoxy)undec-1-en-6-yloxy](tert-butyl)diphenylsilane

[(5R,6R)-5-(methoxymethoxy)undec-1-en-6-yloxy](tert-butyl)diphenylsilane

C₂₃H₃₁NOSi