(E)-6-[4-Azidomethyl-2-methoxy-6-(2-methoxy-ethoxymethoxy)-3-methyl-5-(pyrrolidine-1-carbonyl)-phenyl]-4-methyl-hex-4-enoic acid tert-butyl ester

Base Information

Chemical Name:(E)-6-[4-Azidomethyl-2-methoxy-6-(2-methoxy-ethoxymethoxy)-3-methyl-5-(pyrrolidine-1-carbonyl)-phenyl]-4-methyl-hex-4-enoic acid tert-butyl ester
CAS No.:182009-88-7
Molecular Formula:C₂₉H₄₄N₄O₇
Molecular Weight:560.691
Hs Code.:

(E)-6-[4-Azidomethyl-2-methoxy-6-(2-methoxy-ethoxymethoxy)-3-methyl-5-(pyrrolidine-1-carbonyl)-phenyl]-4-methyl-hex-4-enoic acid tert-butyl ester

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Chemical Property of (E)-6-[4-Azidomethyl-2-methoxy-6-(2-methoxy-ethoxymethoxy)-3-methyl-5-(pyrrolidine-1-carbonyl)-phenyl]-4-methyl-hex-4-enoic acid tert-butyl ester

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Technology Process of (E)-6-[4-Azidomethyl-2-methoxy-6-(2-methoxy-ethoxymethoxy)-3-methyl-5-(pyrrolidine-1-carbonyl)-phenyl]-4-methyl-hex-4-enoic acid tert-butyl ester

There total 8 articles about (E)-6-[4-Azidomethyl-2-methoxy-6-(2-methoxy-ethoxymethoxy)-3-methyl-5-(pyrrolidine-1-carbonyl)-phenyl]-4-methyl-hex-4-enoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 182009-87-6
(E)-6-[4-Methanesulfonyloxymethyl-2-methoxy-6-(2-methoxy-ethoxymethoxy)-3-methyl-5-(pyrrolidine-1-carbonyl)-phenyl]-4-methyl-hex-4-enoic acid tert-butyl ester

: 182009-88-7
(E)-6-[4-Azidomethyl-2-methoxy-6-(2-methoxy-ethoxymethoxy)-3-methyl-5-(pyrrolidine-1-carbonyl)-phenyl]-4-methyl-hex-4-enoic acid tert-butyl ester

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; for 5h;
DOI:10.1021/jm9603633

Reference yield:

: 31858-66-9
methyl mycophenolate

: 182009-88-7
(E)-6-[4-Azidomethyl-2-methoxy-6-(2-methoxy-ethoxymethoxy)-3-methyl-5-(pyrrolidine-1-carbonyl)-phenyl]-4-methyl-hex-4-enoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: diisopropylethylamine / CH₂Cl₂ / 3 h / Ambient temperature

2: 4 N aq, KOH / methanol / 48 h

3: oxalyl chloride, DMF / ethyl acetate / 1 h

4: DMAP / CH₂Cl₂ / 18 h / Ambient temperature

5: 1.) Me₃Al / 1.) THF, toluene, 30 min, 2.) THF, toluene, a) overnight, b) 50 deg C, 24 h

6: triethylamine / CH₂Cl₂ / 1 h / -10 °C

7: 1.38 g / NaN₃ / dimethylformamide / 5 h

With dmap; potassium hydroxide; sodium azide; oxalyl dichloride; trimethylaluminum; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm9603633

Reference yield:

: 24280-93-1
mycophenolic acid

: 182009-88-7
(E)-6-[4-Azidomethyl-2-methoxy-6-(2-methoxy-ethoxymethoxy)-3-methyl-5-(pyrrolidine-1-carbonyl)-phenyl]-4-methyl-hex-4-enoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / TsOH / 18 h / 25 °C

2: diisopropylethylamine / CH₂Cl₂ / 3 h / Ambient temperature

3: 4 N aq, KOH / methanol / 48 h

4: oxalyl chloride, DMF / ethyl acetate / 1 h

5: DMAP / CH₂Cl₂ / 18 h / Ambient temperature

6: 1.) Me₃Al / 1.) THF, toluene, 30 min, 2.) THF, toluene, a) overnight, b) 50 deg C, 24 h

7: triethylamine / CH₂Cl₂ / 1 h / -10 °C

8: 1.38 g / NaN₃ / dimethylformamide / 5 h

With dmap; potassium hydroxide; sodium azide; oxalyl dichloride; trimethylaluminum; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm9603633