7-Fluoronaphthalen-1-ol

Base Information

• Chemical Name: 7-Fluoronaphthalen-1-ol
• CAS No.: 3132-92-1
• Molecular Formula: C₁₀H₇FO
• Molecular Weight: 162.163
• Hs Code.: 2908190090
• Mol file: 3132-92-1.mol

Synonyms:

Chemical Property of 7-Fluoronaphthalen-1-ol

Chemical Property:

• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Fluoronaphthalen-1-ol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-Fluoronaphthalen-1-ol

There total 11 articles about 7-Fluoronaphthalen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

7-fluoro-3,4-dihydronaphthalen-1(2H)-one (2840-44-0) → 7-fluoro-naphthalen-1-ol (3132-92-1)

Guidance literature:

With (difluoroboryl)dimethylglyoximatocobalt(II) bis(acetonitrile); boron trifluoride diethyl etherate; 3-cyano-N-methyl-quinolinium perchlorate; In acetonitrile; at 20 ℃; for 0.5h; Irradiation; Inert atmosphere; Flow reactor;

DOI:10.1039/c9cy00753a

Reference yield: 44.0%

6-fluoro-1,4-epoxy-1,4-dihydronaphthalene (173276-82-9) → 7-fluoro-naphthalen-1-ol (3132-92-1)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at 0 - 20 ℃; for 2h;

DOI:10.1021/acs.joc.9b03217

Reference yield:

fluorobenzene (462-06-6) → 7-fluoro-naphthalen-1-ol (3132-92-1)

Guidance literature:

Multi-step reaction with 4 steps

1: AlCl₃ / 1 h / 95 °C

2: Zn-Hg, aq. HCl / toluene / 1 h / Ambient temperature

3: (i) SOCl₂, (ii) AlCl₃, CS₂

4: S / 0.5 h / 240 - 250 °C

With hydrogenchloride; aluminium trichloride; sulfur; mercury; zinc; In toluene;

upstream raw materials:

7-fluoro-3,4-dihydronaphthalen-1(2H)-one

6-fluoro-1,4-epoxy-1,4-dihydronaphthalene

2,4-difluorobromobenzene

fluorobenzene

Downstream raw materials:

(Z)-3-hydroxy-1,3-diphenyl-2-propen-1-one

Carbanilsaeure-<7-fluor-<1>naphtylester>

Refernces

• 1、 Hornum, Mick,Mulberg, Mads W.,Szomek, Maria,Reinholdt, Peter,Brewer, Jonathan R.,Wüstner, Daniel,Kongsted, Jacob,Nielsen, Poul. "Substituted 9-Diethylaminobenzo[ a]phenoxazin-5-ones (Nile Red Analogues): Synthesis and Photophysical Properties". . p. 1471 - 1488. Retrieved 2021/01/13.
• 2、 He, Xu,Zheng, Yi-Wen,Lei, Tao,Liu, Wen-Qiang,Chen, Bin,Feng, Ke,Tung, Chen-Ho,Wu, Li-Zhu. "Photocatalytic hydrogen evolution of 1-tetralones to α-naphthols by continuous-flow technology". . p. 3337 - 3341. Retrieved 2019/07/10.