octahydro-[1,3]oxazolo[5,4-c]pyridin-2-one hydrochloride

Base Information

• Chemical Name: octahydro-[1,3]oxazolo[5,4-c]pyridin-2-one hydrochloride
• CAS No.: 1427170-55-5
• Molecular Formula: C₆H₁₀N₂O₂*ClH
• Molecular Weight: 178.619
• Mol file: 1427170-55-5.mol

Synonyms:

Chemical Property of octahydro-[1,3]oxazolo[5,4-c]pyridin-2-one hydrochloride

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Hexahydrooxazolo[5,4-c]pyridin-2(1H)-onehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of octahydro-[1,3]oxazolo[5,4-c]pyridin-2-one hydrochloride

There total 4 articles about octahydro-[1,3]oxazolo[5,4-c]pyridin-2-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

2-oxohexahydrooxazo[5,4-c]pyridine-5(2H)-formic acid tert-butyl ester (1427170-53-3) → C6H10N2O2*ClH (1427170-55-5)

Guidance literature:

With hydrogenchloride; In dichloromethane; at 20 ℃; for 3.5h;

DOI:10.1016/j.bmcl.2013.01.048

Reference yield:

ethyl 1-tert-butoxycarbonyl-3-oxopiperidine-4-carboxylate (71233-25-5) → C6H10N2O2*ClH (1427170-55-5)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium borohydride / ethanol / 2 h / 20 °C

2: ammonia; N,N-dimethyl-formamide / water / 36 h / 20 °C

3: sodium hypobromide; water / 8 h / 5 - 80 °C

4: hydrogenchloride / dichloromethane / 3.5 h / 20 °C

With hydrogenchloride; sodium hypobromide; potassium borohydride; ammonia; water; N,N-dimethyl-formamide; In ethanol; dichloromethane; water; 3: |Hofmann Rearrangement;

DOI:10.1016/j.bmcl.2013.01.048

Reference yield:

3-hydroxypiperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (71233-28-8,217488-49-8) → C6H10N2O2*ClH (1427170-55-5)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonia; N,N-dimethyl-formamide / water / 36 h / 20 °C

2: sodium hypobromide; water / 8 h / 5 - 80 °C

3: hydrogenchloride / dichloromethane / 3.5 h / 20 °C

With hydrogenchloride; sodium hypobromide; ammonia; water; N,N-dimethyl-formamide; In dichloromethane; water; 2: |Hofmann Rearrangement;

DOI:10.1016/j.bmcl.2013.01.048

upstream raw materials:

2-oxohexahydrooxazo[5,4-c]pyridine-5(2H)-formic acid tert-butyl ester

ethyl 1-tert-butoxycarbonyl-3-oxopiperidine-4-carboxylate

3-hydroxypiperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

C₁₁H₂₀N₂O₄