dl-β-costol

Base Information

• Chemical Name: dl-β-costol
• CAS No.: 72057-07-9
• Molecular Formula: C₁₅H₂₄O
• Molecular Weight: 220.355
• Mol file: 72057-07-9.mol

Synonyms:

Chemical Property of dl-β-costol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dl-β-costol

There total 17 articles about dl-β-costol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

dimethyl (trans-4aβ-methyl-1-methylene-7β-decalinyl)malonate → trans-7β-(2-hydroxy-1-methylethyl)-4aβ-methyl-1-methylenedecalin (4700-80-5) + dl-β-costol (515-20-8,69427-73-2,72057-07-9,77171-51-8,97371-99-8)

Guidance literature:

With sodium hydride; sodium bis(2-methoxyethoxy)aluminium dihydride; Yield given. Multistep reaction; 1.) DME, 24 h, reflux, 2.) benzene DME, 1 h, reflux;

DOI:10.1246/bcsj.53.2642

Reference yield:

germacra-1(10),4,11(13)-trien-12-ol (347377-91-7) → (+)-β-costol (69427-73-2,72057-07-9,77171-51-8,97371-99-8,515-20-8) + γ-costol (65018-14-6) + 2-(2R,4aR,8aR)-(4a,8-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-2-yl)prop-2-en-1-ol (65018-15-7)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 0.116667h;

DOI:10.1016/S0031-9422(01)00291-6

Reference yield:

2α-hydroxy-4aβ-methyldecalin-8-one → dl-β-costol (515-20-8,69427-73-2,72057-07-9,77171-51-8,97371-99-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 97 percent / pyridine / 20 h / 5 °C

2: 82 percent / 1,2-dimethoxy-ethane / 36 h / Heating

3: 86 percent / benzene / 20 h / Ambient temperature

4: 1.) NaH, 2.) NaAl(OCH₂CH₂OCH₃)2H₂ / 1.) DME, 24 h, reflux, 2.) benzene DME, 1 h, reflux

With pyridine; sodium hydride; sodium bis(2-methoxyethoxy)aluminium dihydride; In 1,2-dimethoxyethane; benzene;

DOI:10.1246/bcsj.53.2642

upstream raw materials:

germacra-1⁽¹⁰⁾,4,11⁽¹³⁾-trien-12-ol

beta-selinene

dl-β-costal

Methanesulfonic acid (2S,4aR,8aS)-4a-methyl-8-methylene-decahydro-naphthalen-2-yl ester

Downstream raw materials:

dl-β-costal

costal