(2S,4S,5R,4'S,5'S)-4-Methyl-2'-oxo-5-phenyl-3-(toluene-4-sulfonyl)-[2,5']bioxazolidinyl-3',4'-dicarboxylic acid 3'-tert-butyl ester 4'-methyl ester

Base Information

Chemical Name:(2S,4S,5R,4'S,5'S)-4-Methyl-2'-oxo-5-phenyl-3-(toluene-4-sulfonyl)-[2,5']bioxazolidinyl-3',4'-dicarboxylic acid 3'-tert-butyl ester 4'-methyl ester
CAS No.:119588-79-3
Molecular Formula:C₂₇H₃₂N₂O₉S
Molecular Weight:560.625
Hs Code.:

(2S,4S,5R,4'S,5'S)-4-Methyl-2'-oxo-5-phenyl-3-(toluene-4-sulfonyl)-[2,5']bioxazolidinyl-3',4'-dicarboxylic acid 3'-tert-butyl ester 4'-methyl ester

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Chemical Property of (2S,4S,5R,4'S,5'S)-4-Methyl-2'-oxo-5-phenyl-3-(toluene-4-sulfonyl)-[2,5']bioxazolidinyl-3',4'-dicarboxylic acid 3'-tert-butyl ester 4'-methyl ester

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Technology Process of (2S,4S,5R,4'S,5'S)-4-Methyl-2'-oxo-5-phenyl-3-(toluene-4-sulfonyl)-[2,5']bioxazolidinyl-3',4'-dicarboxylic acid 3'-tert-butyl ester 4'-methyl ester

There total 13 articles about (2S,4S,5R,4'S,5'S)-4-Methyl-2'-oxo-5-phenyl-3-(toluene-4-sulfonyl)-[2,5']bioxazolidinyl-3',4'-dicarboxylic acid 3'-tert-butyl ester 4'-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 119618-52-9
(2S,4S,5R,4'S,5'S)-4-Methyl-2'-oxo-5-phenyl-3-(toluene-4-sulfonyl)-[2,5']bioxazolidinyl-4'-carboxylic acid methyl ester

: 119588-79-3,119618-53-0
(2S,4S,5R,4'S,5'S)-4-Methyl-2'-oxo-5-phenyl-3-(toluene-4-sulfonyl)-[2,5']bioxazolidinyl-3',4'-dicarboxylic acid 3'-tert-butyl ester 4'-methyl ester

Guidance literature:: With dmap; In tetrahydrofuran; for 4h; Ambient temperature;
DOI:10.1016/S0040-4020(01)86061-0

Reference yield: 80.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 119588-78-2
(2S,4S,5R,4'R,5'S)-4-Methyl-2'-oxo-5-phenyl-3-(toluene-4-sulfonyl)-[2,5']bioxazolidinyl-4'-carboxylic acid methyl ester

: 119588-79-3,119618-53-0
(2S,4S,5R,4'R,5'S)-4-Methyl-2'-oxo-5-phenyl-3-(toluene-4-sulfonyl)-[2,5']bioxazolidinyl-3',4'-dicarboxylic acid 3'-tert-butyl ester 4'-methyl ester

Guidance literature:: With dmap; In tetrahydrofuran; for 4h; Ambient temperature;
DOI:10.1016/S0040-4020(01)86061-0

Reference yield:

: 108591-33-9
N-((1R,2S)-1-hydroxy-1-phenylpropan-2-yl)-4-methylbenzene sulfonamide

: 119588-79-3,119618-53-0
(2S,4S,5R,4'R,5'S)-4-Methyl-2'-oxo-5-phenyl-3-(toluene-4-sulfonyl)-[2,5']bioxazolidinyl-3',4'-dicarboxylic acid 3'-tert-butyl ester 4'-methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / pyridinium tosylate / benzene / 0.5 h / Heating

2: Amberlyst-15 / acetone; H₂O / 3 h / Ambient temperature

3: 90 percent / KClO / tetrahydrofuran; H₂O / 1 h 0 degC then 2 h r.t.

4: NH₃ / H₂O / 3 h / 70 °C

5: 1.) KOH / 1.) THF, toluene, 0 degC, 30 min; 2.) ethyl ether, MeOH

6: 80 percent / 4-dimethylamino pyridine / tetrahydrofuran / 4 h / Ambient temperature

With dmap; potassium hydroxide; potassium hypochlorite; amberlyst-15; ammonia; pyridinium p-toluenesulfonate; In tetrahydrofuran; water; acetone; benzene;
DOI:10.1016/S0040-4020(01)86061-0