[(2R,4S,5S,6R)-6-(5,5-Dimethyl-[1,3]dioxan-2-ylmethyl)-4-(4-methoxy-benzyloxy)-5-methyl-5-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-methanol

Base Information

Chemical Name:[(2R,4S,5S,6R)-6-(5,5-Dimethyl-[1,3]dioxan-2-ylmethyl)-4-(4-methoxy-benzyloxy)-5-methyl-5-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-methanol
CAS No.:612846-87-4
Molecular Formula:C₃₂H₅₆O₇Si
Molecular Weight:580.878
Hs Code.:

[(2R,4S,5S,6R)-6-(5,5-Dimethyl-[1,3]dioxan-2-ylmethyl)-4-(4-methoxy-benzyloxy)-5-methyl-5-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-methanol

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Chemical Property of [(2R,4S,5S,6R)-6-(5,5-Dimethyl-[1,3]dioxan-2-ylmethyl)-4-(4-methoxy-benzyloxy)-5-methyl-5-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-methanol

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Technology Process of [(2R,4S,5S,6R)-6-(5,5-Dimethyl-[1,3]dioxan-2-ylmethyl)-4-(4-methoxy-benzyloxy)-5-methyl-5-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-methanol

There total 11 articles about [(2R,4S,5S,6R)-6-(5,5-Dimethyl-[1,3]dioxan-2-ylmethyl)-4-(4-methoxy-benzyloxy)-5-methyl-5-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Benzoic acid (2R,4S,5S,6R)-6-(5,5-dimethyl-[1,3]dioxan-2-ylmethyl)-4-(4-methoxy-benzyloxy)-5-methyl-5-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-ylmethyl ester

: 612846-87-4
[(2R,4S,5S,6R)-6-(5,5-Dimethyl-[1,3]dioxan-2-ylmethyl)-4-(4-methoxy-benzyloxy)-5-methyl-5-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-methanol

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃;
DOI:10.1016/S0040-4039(03)01748-9

Reference yield:

: 532-32-1
sodium benzoate

: 612846-87-4
[(2R,4S,5S,6R)-6-(5,5-Dimethyl-[1,3]dioxan-2-ylmethyl)-4-(4-methoxy-benzyloxy)-5-methyl-5-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: I₂; K₂CO₃ / acetonitrile / -25 - -15 °C

1.2: 1-methyl-pyrrolidin-2-one / 100 °C

2.1: OsO₄; NaIO₄ / methanol; H₂O; tetrahydrofuran / 0 °C

3.1: p-TsOH / toluene / 80 °C

4.1: K₂CO₃ / methanol / 20 °C

With sodium periodate; osmium(VIII) oxide; iodine; potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; water; toluene; acetonitrile; 3.1: Mitsunobu reaction;
DOI:10.1016/S0040-4039(03)01748-9

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 612846-87-4
[(2R,4S,5S,6R)-6-(5,5-Dimethyl-[1,3]dioxan-2-ylmethyl)-4-(4-methoxy-benzyloxy)-5-methyl-5-triisopropylsilanyloxymethyl-tetrahydro-pyran-2-yl]-methanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: DMAP; Et₃N / CH₂Cl₂ / 20 °C

2.1: I₂; K₂CO₃ / acetonitrile / -25 - -15 °C

2.2: 1-methyl-pyrrolidin-2-one / 100 °C

3.1: OsO₄; NaIO₄ / methanol; H₂O; tetrahydrofuran / 0 °C

4.1: p-TsOH / toluene / 80 °C

5.1: K₂CO₃ / methanol / 20 °C

With dmap; sodium periodate; osmium(VIII) oxide; iodine; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile; 4.1: Mitsunobu reaction;
DOI:10.1016/S0040-4039(03)01748-9