(6R)-3-((3Ξ)-4ξ-methoxycarbonyl-2-methyl-isoxazolidin-3r-yl)-5ξ,8-dioxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Base Information

• Chemical Name: (6R)-3-((3Ξ)-4ξ-methoxycarbonyl-2-methyl-isoxazolidin-3r-yl)-5ξ,8-dioxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester
• CAS No.: 55570-01-9
• Molecular Formula: C₃₂H₃₁N₃O₈S₂
• Molecular Weight: 649.745

Synonyms:

Chemical Property of (6R)-3-((3Ξ)-4ξ-methoxycarbonyl-2-methyl-isoxazolidin-3r-yl)-5ξ,8-dioxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (6R)-3-((3Ξ)-4ξ-methoxycarbonyl-2-methyl-isoxazolidin-3r-yl)-5ξ,8-dioxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

There total 3 articles about (6R)-3-((3Ξ)-4ξ-methoxycarbonyl-2-methyl-isoxazolidin-3r-yl)-5ξ,8-dioxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(6R)-3-[(methyl-oxy-imino)-methyl]-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2c-carboxylic acid benzhydryl ester (55569-95-4) → (6R)-3-((3Ξ)-4ξ-methoxycarbonyl-2-methyl-isoxazolidin-3r-yl)-5ξ,8-dioxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5λ4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (55570-01-9)

Guidance literature:

Multi-step reaction with 2 steps

1: MCPBA / CHCl₃

2: Heating

With 3-chloro-benzenecarboperoxoic acid; In chloroform;

DOI:10.1021/jo00904a036

Reference yield:

(6R)-3-formyl-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2c-carboxylic acid benzhydryl ester (55331-32-3) → (6R)-3-((3Ξ)-4ξ-methoxycarbonyl-2-methyl-isoxazolidin-3r-yl)-5ξ,8-dioxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5λ4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (55570-01-9)

Guidance literature:

Multi-step reaction with 3 steps

1: Py / CH₂Cl₂; ethanol / Heating

2: MCPBA / CHCl₃

3: Heating

With pyridine; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; chloroform;

DOI:10.1021/jo00904a036

Reference yield:

(6R)-3-[(methyl-oxy-imino)-methyl]-5ξ,8-dioxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5λ4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (55569-96-5) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → (6R)-3-((3Ξ)-4ξ-methoxycarbonyl-2-methyl-isoxazolidin-3r-yl)-5ξ,8-dioxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5λ4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester (55570-01-9)

Guidance literature:

Heating;

DOI:10.1021/jo00904a036

upstream raw materials:

(6R)-3-[(methyl-oxy-imino)-methyl]-5ξ,8-dioxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

acrylic acid methyl ester

(6R)-3-[(methyl-oxy-imino)-methyl]-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2c-carboxylic acid benzhydryl ester

(6R)-3-formyl-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2c-carboxylic acid benzhydryl ester

Downstream raw materials:

(6R)-3-((3Ξ)-4ξ-methoxycarbonyl-2-methyl-isoxazolidin-3r-yl)-8-oxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester

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