(2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-hexanoic acid butyl-methyl-amide

Base Information

Chemical Name:(2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-hexanoic acid butyl-methyl-amide
CAS No.:128901-43-9
Molecular Formula:C₄₁H₅₈N₈O₃
Molecular Weight:710.963
Hs Code.:

(2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-hexanoic acid butyl-methyl-amide

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Chemical Property of (2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-hexanoic acid butyl-methyl-amide

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Technology Process of (2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-hexanoic acid butyl-methyl-amide

There total 9 articles about (2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-hexanoic acid butyl-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 110-68-9
N-n-butyl-N-methylamine

: 128901-48-4,128948-73-2,130321-45-8
N-[(S)-2-Cyclohexyl-1-((2S,4S)-4-isopropyl-5-oxo-tetrahydro-furan-2-yl)-ethyl]-2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionamide

: 128901-43-9,128948-69-6,130321-41-4
(2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-hexanoic acid butyl-methyl-amide

Guidance literature:: With dimethylaluminum chloride; In hexane; dichloromethane; for 6h; Heating;
DOI:10.1021/jm00171a006

Reference yield:

: 128901-46-2
(E)-1-chloro-4-cyclohexyl-2-butene

: 128901-43-9,128948-69-6,130321-41-4
(2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-hexanoic acid butyl-methyl-amide

Guidance literature:: Multi-step reaction with 7 steps

1: 77 percent / NaI / acetone

2: 1.) LDA / 1.) hexane, THF, -40 deg C, 0.5 h, 2.) 0 deg C, 1 h

3: 97 percent / N-bromosuccinimide / H₂O; 1,2-dimethoxy-ethane / 0.17 h / 0 °C

4: NaN₃, DMPU

5: 100 percent / H₂ / 10percent Pd/C / ethanol / 20 °C / 760 Torr

6: 69 percent / 1-hydroxybenzotriazole hydrate (HOBT), 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC) / H₂O; dimethylformamide

7: 20 percent / 1 M dimethylaluminium chloride / hexane; CH₂Cl₂ / 6 h / Heating

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N-Bromosuccinimide; sodium azide; hydrogen; dimethylaluminum chloride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium iodide; lithium diisopropyl amide; palladium on activated charcoal; In 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00171a006

Reference yield:

: 145589-03-3,104266-90-2
(S)-4-benzyl-3-(3-methylbutanoyl)oxazolidin-2-one

: 128901-43-9,128948-69-6,130321-41-4
(2S,4S,5S)-6-Cyclohexyl-4-hydroxy-2-isopropyl-5-[2-(8-propyl-6-pyridin-3-yl-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-3-pyridin-3-yl-propionylamino]-hexanoic acid butyl-methyl-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) LDA / 1.) hexane, THF, -40 deg C, 0.5 h, 2.) 0 deg C, 1 h

2: 97 percent / N-bromosuccinimide / H₂O; 1,2-dimethoxy-ethane / 0.17 h / 0 °C

3: NaN₃, DMPU

4: 100 percent / H₂ / 10percent Pd/C / ethanol / 20 °C / 760 Torr

5: 69 percent / 1-hydroxybenzotriazole hydrate (HOBT), 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC) / H₂O; dimethylformamide

6: 20 percent / 1 M dimethylaluminium chloride / hexane; CH₂Cl₂ / 6 h / Heating

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N-Bromosuccinimide; sodium azide; hydrogen; dimethylaluminum chloride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; palladium on activated charcoal; In 1,2-dimethoxyethane; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a006