(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenyl-2-{[1-phenyl-meth-(E)-ylidene]-amino}-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

Base Information

• Chemical Name: (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenyl-2-{[1-phenyl-meth-(E)-ylidene]-amino}-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid
• CAS No.: 1256-08-2
• Molecular Formula: C₂₃H₂₃N₃O₄S
• Molecular Weight: 437.519

Synonyms:

Chemical Property of (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenyl-2-{[1-phenyl-meth-(E)-ylidene]-amino}-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenyl-2-{[1-phenyl-meth-(E)-ylidene]-amino}-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid

There total 3 articles about (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenyl-2-{[1-phenyl-meth-(E)-ylidene]-amino}-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenyl-2-{[1-phenyl-meth-(E)-ylidene]-amino}-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 1-ethoxycarbonyloxy-ethyl ester (96606-98-3) → bacampicillin hydrochloride (37661-08-8,95530-84-0,95530-85-1) + (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenyl-2-{[1-phenyl-meth-(E)-ylidene]-amino}-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (1256-08-2,6490-08-0)

Guidance literature:

With water; at 35 ℃; Rate constant; degradation in various buffers (pH 7.00-9.00);

DOI:10.1248/cpb.33.1202

Reference yield:

benzaldehyde (100-52-7) + ampicillin trihydrate (5187-94-0,7177-48-2,32388-53-7,57095-77-9,145454-26-8) → (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenyl-2-{[1-phenyl-meth-(E)-ylidene]-amino}-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (1256-08-2)

Guidance literature:

With potassium hydrogencarbonate; In N,N-dimethyl-formamide; at 0 - 5 ℃; for 3h;

DOI:10.1248/cpb.31.2698

Reference yield:

benzaldehyde (100-52-7) + ampicillin (33993-48-5) → (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenyl-2-{[1-phenyl-meth-(E)-ylidene]-amino}-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (1256-08-2)

Guidance literature:

In water; at 0 ℃; for 72h;

DOI:10.1248/cpb.30.3310

upstream raw materials:

benzaldehyde

ampicillin trihydrate

ampicillin

(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenyl-2-{[1-phenyl-meth-(E)-ylidene]-amino}-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 1-ethoxycarbonyloxy-ethyl ester

Downstream raw materials:

(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenyl-2-{[1-phenyl-meth-(E)-ylidene]-amino}-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 2-[3-oxo-3H-isobenzofuran-(1Z)-ylidene]-ethyl ester

ampicillin (3-phthalidylidene)ethyl ester hydrochloride

ampicillin (3-(2-thiophthalidylidene))ethyl ester hydrochloride

ampicillin (3-(6-methoxyphthalidylidene))ethyl ester hydrochloride

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