(R)-2-(4-Chloro-benzoylamino)-pentanedioic acid 5-[((S)-1-carbamoyl-2-phenyl-ethyl)-amide] 1-dipropylamide

Base Information

Chemical Name:(R)-2-(4-Chloro-benzoylamino)-pentanedioic acid 5-[((S)-1-carbamoyl-2-phenyl-ethyl)-amide] 1-dipropylamide
CAS No.:120452-37-1
Molecular Formula:C₂₇H₃₅ClN₄O₄
Molecular Weight:515.052
Hs Code.:

Synonyms:

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Chemical Property of (R)-2-(4-Chloro-benzoylamino)-pentanedioic acid 5-[((S)-1-carbamoyl-2-phenyl-ethyl)-amide] 1-dipropylamide

Chemical Property:

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Technology Process of (R)-2-(4-Chloro-benzoylamino)-pentanedioic acid 5-[((S)-1-carbamoyl-2-phenyl-ethyl)-amide] 1-dipropylamide

There total 7 articles about (R)-2-(4-Chloro-benzoylamino)-pentanedioic acid 5-[((S)-1-carbamoyl-2-phenyl-ethyl)-amide] 1-dipropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 142-84-7
di-n-propylamine

: 120452-37-1
(R)-2-(4-Chloro-benzoylamino)-pentanedioic acid 5-[((S)-1-carbamoyl-2-phenyl-ethyl)-amide] 1-dipropylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NEt₃, ethyl chloroformate / 1.) THF, -15 - 0 deg C, 10 min, 2.) THF, -10 - 0 deg C, 6 h

2: 1N NaOH / tetrahydrofuran / 2 h / Ambient temperature

3: 1.) ethyl chloroformate, NEt₃, 2.) NEt₃ / 1.) THF, -15- -10 deg C, 10 min, 2.) THF, -10- 0 deg C, 5 h

4: H₂ / 10percent Pd-C / dioxane; aq. HCl / 2 h / Ambient temperature

5: NaHCO₃ / H₂O; diethyl ether / 3 h

With sodium hydroxide; hydrogen; chloroformic acid ethyl ester; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; hydrogenchloride; diethyl ether; water;
DOI:10.1248/cpb.36.3433

Reference yield:

: 27025-24-7
Z-D-glutamic γ-methyl ester

: 120452-37-1
(R)-2-(4-Chloro-benzoylamino)-pentanedioic acid 5-[((S)-1-carbamoyl-2-phenyl-ethyl)-amide] 1-dipropylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NEt₃, ethyl chloroformate / 1.) THF, -15 - 0 deg C, 10 min, 2.) THF, -10 - 0 deg C, 6 h

2: 1N NaOH / tetrahydrofuran / 2 h / Ambient temperature

3: 1.) ethyl chloroformate, NEt₃, 2.) NEt₃ / 1.) THF, -15- -10 deg C, 10 min, 2.) THF, -10- 0 deg C, 5 h

4: H₂ / 10percent Pd-C / dioxane; aq. HCl / 2 h / Ambient temperature

5: NaHCO₃ / H₂O; diethyl ether / 3 h

With sodium hydroxide; hydrogen; chloroformic acid ethyl ester; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; hydrogenchloride; diethyl ether; water;
DOI:10.1248/cpb.36.3433

Reference yield:

: 63648-73-7
N-benzyloxycarbonyl-D-glutamic acid

: 120452-37-1
(R)-2-(4-Chloro-benzoylamino)-pentanedioic acid 5-[((S)-1-carbamoyl-2-phenyl-ethyl)-amide] 1-dipropylamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) paraformaldehyde, p-toluenesulfonic acid hydrate / 1.) benzene, 2.) THF, reflux, 8 h

2: 1.) ethyl chloroformate, NEt₃, 2.) NEt₃ / 1.) THF, -15- -10 deg C, 10 min, 2.) THF, -10- 0 deg C, 5 h

3: H₂ / 10percent Pd-C / dioxane; aq. HCl / 2 h / Ambient temperature

4: NaHCO₃ / H₂O; diethyl ether / 3 h

With formaldehyd; hydrogen; chloroformic acid ethyl ester; sodium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In 1,4-dioxane; hydrogenchloride; diethyl ether; water;
DOI:10.1248/cpb.36.3433