Methanesulfonic acid (5aS,6aR,9R,10R,10aS)-10-hydroxy-4-(4-methoxy-benzenesulfonyl)-7-methyl-4,5,5a,6,6a,7,8,9,10,10a-decahydro-indolo[4,3-fg]quinolin-9-ylmethyl ester

Base Information

• Chemical Name: Methanesulfonic acid (5aS,6aR,9R,10R,10aS)-10-hydroxy-4-(4-methoxy-benzenesulfonyl)-7-methyl-4,5,5a,6,6a,7,8,9,10,10a-decahydro-indolo[4,3-fg]quinolin-9-ylmethyl ester
• CAS No.: 99499-50-0
• Molecular Formula: C₂₄H₃₀N₂O₇S₂
• Molecular Weight: 522.643

Synonyms:

Chemical Property of Methanesulfonic acid (5aS,6aR,9R,10R,10aS)-10-hydroxy-4-(4-methoxy-benzenesulfonyl)-7-methyl-4,5,5a,6,6a,7,8,9,10,10a-decahydro-indolo[4,3-fg]quinolin-9-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (5aS,6aR,9R,10R,10aS)-10-hydroxy-4-(4-methoxy-benzenesulfonyl)-7-methyl-4,5,5a,6,6a,7,8,9,10,10a-decahydro-indolo[4,3-fg]quinolin-9-ylmethyl ester

There total 19 articles about Methanesulfonic acid (5aS,6aR,9R,10R,10aS)-10-hydroxy-4-(4-methoxy-benzenesulfonyl)-7-methyl-4,5,5a,6,6a,7,8,9,10,10a-decahydro-indolo[4,3-fg]quinolin-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(3α,8α,9α,10α)-2,3-Dihydro-8-hydroxymethyl-1-<(4-methoxyphenyl)sulfonyl>-6-methylergolin-9-ol (89651-11-6,89708-35-0) → Methanesulfonic acid (5aS,6aR,9R,10R,10aS)-10-hydroxy-4-(4-methoxy-benzenesulfonyl)-7-methyl-4,5,5a,6,6a,7,8,9,10,10a-decahydro-indolo[4,3-fg]quinolin-9-ylmethyl ester (99499-50-0,101978-96-5)

Guidance literature:

With pyridine; at 0 ℃;

Reference yield: 89.0%

(3β,8α,9α)-2,3-Dihydro-8-hydroxymethyl-1-<(4-methoxyphenyl)sulfonyl>-6-methylergolin-9-ol (89651-11-6,89708-35-0) + methanesulfonyl chloride (124-63-0) → (3β,8α,9α)-2,3-Dihydro-8-methanesulfonyloxymethyl-1-<(4-methoxyphenyl)sulfonyl>-6-methylergolin-9-ol (99499-50-0,101978-96-5)

Guidance literature:

With pyridine; at 0 ℃; for 3.5h;

DOI:10.1248/cpb.39.23

Reference yield: 81.0%

(3α,8α,9α,10α)-2,3-Dihydro-8-hydroxymethyl-1-<(4-methoxyphenyl)sulfonyl>-6-methylergolin-9-ol (89651-11-6,89708-35-0) + methanesulfonyl chloride (124-63-0) → Methanesulfonic acid (5aS,6aR,9R,10R,10aS)-10-hydroxy-4-(4-methoxy-benzenesulfonyl)-7-methyl-4,5,5a,6,6a,7,8,9,10,10a-decahydro-indolo[4,3-fg]quinolin-9-ylmethyl ester (99499-50-0,101978-96-5)

Guidance literature:

With pyridine; at 0 ℃; for 3.5h;

DOI:10.1248/cpb.39.23

upstream raw materials:

(3β,8α,9α)-2,3-Dihydro-8-hydroxymethyl-1-<(4-methoxyphenyl)sulfonyl>-6-methylergolin-9-ol

methanesulfonyl chloride

1-benzoyl-1,2,2a,3-tetrahydro-benz[cd]indole

1-<(4-Methoxyphenyl)sulfonyl>-1,2,2a,3-tetrahydrobenzindole

Downstream raw materials:

(3β,8α,9α)-2,3-Dihydro-1-<(4-methoxyphenyl)sulfonyl>-6,8-dimethylergolin-9-ol

(3β,8α,9β)-9-Chloro-2,3-dihydro-1-<(4-methoxyphenyl)sulfonyl>-6,8-dimethylergoline

(+/-)-Agroclavine

(3β,8α,9β)-8,9-Didehydro-2,3-dihydro-1-<(4-methoxyphenyl)sulfonyl>-6,8-dimethylergoline

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