(R)-8-Chloromethyl-4-hydroxy-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-2-carboxylic acid methyl ester

Base Information

Chemical Name:(R)-8-Chloromethyl-4-hydroxy-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-2-carboxylic acid methyl ester
CAS No.:152785-82-5
Molecular Formula:C₂₅H₂₄ClN₃O₇
Molecular Weight:513.934
Hs Code.:

(R)-8-Chloromethyl-4-hydroxy-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-2-carboxylic acid methyl ester

Synonyms:

Suppliers and Price of (R)-8-Chloromethyl-4-hydroxy-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-2-carboxylic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 5 raw suppliers

Chemical Property of (R)-8-Chloromethyl-4-hydroxy-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-2-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
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Useful:

Technology Process of (R)-8-Chloromethyl-4-hydroxy-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-2-carboxylic acid methyl ester

There total 54 articles about (R)-8-Chloromethyl-4-hydroxy-6-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 130288-24-3
(+)-duocarmycin SA

: 144667-38-9,152785-82-5
duocarmycin

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 0 ℃; for 0.25h;
DOI:10.1021/ja00073a019

Reference yield: 91.0%

: 539856-47-8
methyl (1R/S)-5-benzyloxy-1-(chloromethyl)-3-[(5,6,7-trimethoxyindole-2-yl)carbonyl]-1,2-dihydro-3H-pyrrolo[3,2-e]indole-7-carboxylate

: 144667-38-9,152785-82-5
methyl (1R/S)-1-(chloromethyl)-5-hydroxy-3-[(5,6,7-trimethoxyindole-2-yl)carbonyl]-1,2-dihydro-3H-pyrrolo[3,2-e]indole-7-carboxylate

Guidance literature:: With ammonium formate; palladium on activated charcoal; In tetrahydrofuran; at 40 ℃; for 4h;
DOI:10.1002/ejoc.200390094

Reference yield: 73.0%

: 128781-07-7
5,6,7-trimethoxy-1H-indole-2-carboxylic acid

: methyl 1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-pyrrolo<3,2-e>indole-7-carboxylate hydrochloride salt

: 144667-38-9,152785-82-5
methyl (1R/S)-1-(chloromethyl)-5-hydroxy-3-[(5,6,7-trimethoxyindole-2-yl)carbonyl]-1,2-dihydro-3H-pyrrolo[3,2-e]indole-7-carboxylate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 25 ℃; for 15h;
DOI:10.1021/ja00073a019