N-[(trans)-4-[4-(Cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-7-[[(7R)-7-ethyl-8-isopropyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carboxamide

Base Information

Chemical Name:N-[(trans)-4-[4-(Cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-7-[[(7R)-7-ethyl-8-isopropyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carboxamide
CAS No.:1280665-36-2
Molecular Formula:C₃₅H₅₀N₈O₃
Molecular Weight:630.834
Hs Code.:

N-[(trans)-4-[4-(Cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-7-[[(7R)-7-ethyl-8-isopropyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(trans)-4-[4-(Cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-7-[[(7R)-7-ethyl-8-isopropyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-[(trans)-4-[4-(Cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-7-[[(7R)-7-ethyl-8-isopropyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carboxamide

There total 15 articles about N-[(trans)-4-[4-(Cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-7-[[(7R)-7-ethyl-8-isopropyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 149506-79-6
4-(dibenzylamino)cyclohexanone

: 1280665-36-2
N-[(trans)-4-[4-(Cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-7-[[(7R)-7-ethyl-8-isopropyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium acetate; sodium tris(acetoxy)borohydride / acetonitrile / 12 h / 20 - 30 °C / pH 6 - 7

1.2: pH 8

2.1: hydrogen; acetic acid / palladium 10% on activated carbon / methanol / 12 h / 20 - 30 °C / 2280.15 Torr

3.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 2 h / 20 - 30 °C / Inert atmosphere

With hydrogen; sodium acetate; sodium tris(acetoxy)borohydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; dichloromethane; acetonitrile;

Reference yield:

: 755039-89-5
(trans)-N,N-dibenzyl-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexanamine

: 1280665-36-2
N-[(trans)-4-[4-(Cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-7-[[(7R)-7-ethyl-8-isopropyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; acetic acid / palladium 10% on activated carbon / methanol / 12 h / 20 - 30 °C / 2280.15 Torr

2: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 2 h / 20 - 30 °C / Inert atmosphere

With hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; dichloromethane;

Reference yield:

: 619-14-7
3-hydroxy-4-nitro-benzoic acid

: 1280665-36-2
N-[(trans)-4-[4-(Cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-7-[[(7R)-7-ethyl-8-isopropyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,3-dihydrobenzofuran-4-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: thionyl chloride / 2 h / 0 °C / Reflux; Inert atmosphere

2.1: potassium carbonate / acetonitrile / 3 h / Reflux; Inert atmosphere

3.1: 3 h / 190 °C / Inert atmosphere

4.1: Oxone / dichloromethane; methanol / 1.17 h / -78 °C / Inert atmosphere

4.2: 3 h / 20 °C / Inert atmosphere

5.1: phosphoric acid / 0.33 h / 100 °C / Inert atmosphere

6.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 - 30 °C / 2280.15 Torr / Cooling with ice

7.1: water; lithium hydroxide / tetrahydrofuran; methanol / 17 h / 20 - 30 °C / Inert atmosphere; Reflux

7.2: pH 3

8.1: hydrogenchloride / ethanol; water / 15 h / Reflux

9.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 2 h / 20 - 30 °C / Inert atmosphere

With hydrogenchloride; Oxone; thionyl chloride; phosphoric acid; water; hydrogen; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetonitrile;