Technology Process of (1R,3S,5R)-3-<1-Methyl-3-butenyl>-3,6,6-trimethylbicyclo<3.1.1>heptan-2-one
There total 1 articles about (1R,3S,5R)-3-<1-Methyl-3-butenyl>-3,6,6-trimethylbicyclo<3.1.1>heptan-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 88 percent / triethylamine / dimethylformamide / 24 h / 95 °C
2: 96 percent / TiCl4 / CH2Cl2 / 1.5 h / -78 °C
3: 90 percent / p-toluenesulfonic acid / benzene / 2 h / Heating
4: 89 percent / TiCl4 / CH2Cl2 / 2 h / -78 °C
5: 72 percent / NaNH2 / benzene / 1.) reflux, 5 h; 2.) 45 deg C, 17.5 h.
With
titanium tetrachloride; toluene-4-sulfonic acid; sodium amide; triethylamine;
In
dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo01292a010
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) mercuric acetate; 2.) LiCl, PdCl2, CuCl2. / 1.) room temperature, CH3OH, 15 min; 2.) 55 deg C, CH3OH, 1 hour.
2: 73 percent / HCl / acetic acid / 21 h / Ambient temperature
3: Al2O3 / hexane / 24 h / 60 °C
With
hydrogenchloride; aluminum oxide; mercury(II) diacetate; lithium chloride; copper dichloride; palladium dichloride;
In
hexane; acetic acid;
DOI:10.1021/jo01292a010
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) mercuric acetate; 2.) LiCl, PdCl2, CuCl2. / 1.) room temperature, CH3OH, 15 min; 2.) 55 deg C, CH3OH, 1 hour.
2: 73 percent / HCl / acetic acid / 21 h / Ambient temperature
3: 81 percent / SiO2 / CHCl3 / 27 h / 60 °C
With
hydrogenchloride; mercury(II) diacetate; silica gel; lithium chloride; copper dichloride; palladium dichloride;
In
chloroform; acetic acid;
DOI:10.1021/jo01292a010
