Technology Process of 3,5-dichloro-2-methyl-6-phenylpyrazine 1-oxide
There total 10 articles about 3,5-dichloro-2-methyl-6-phenylpyrazine 1-oxide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
maleic anhydride; dihydrogen peroxide;
In
chloroform;
1.) room temperature, overnight; 2.) reflux, 4 h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 31 percent / POCl3 / 1 h / Heating
2: 22 percent / 90percent H2O2, maleic anhydride / CHCl3 / 1.) room temperature, overnight; 2.) reflux, 3 h
3: 92 percent / POCl3 / 1 h / Heating
4: 51 percent / 90percent H2O2, maleic anhydride / CHCl3 / 1.) room temperature, overnight; 2.) reflux, 4 h
With
maleic anhydride; dihydrogen peroxide; trichlorophosphate;
In
chloroform;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 51 percent / PCl5, POCl3 / 1 h / 140 °C / Heating; sealed tube
2: 18 percent / 90percent H2O2, maleic anhydride / CHCl3 / 1.) room temperature, overnight; 2.) reflux, 3 h
3: 95 percent / tetrakis(triphenylphosphine)palladium, sodium formate / dimethylformamide / 2 h / 100 °C
4: 29 percent / POCl3 / 1 h / Heating
5: 17 percent / 90percent H2O2, maleic anhydride / CHCl3 / 1.) room temperature, overnight; 2.) reflux, 3 h
6: 90 percent / POCl3 / 1 h / Heating
7: 51 percent / 90percent H2O2, maleic anhydride / CHCl3 / 1.) room temperature, overnight; 2.) reflux, 4 h
With
maleic anhydride; tetrakis(triphenylphosphine) palladium(0); phosphorus pentachloride; dihydrogen peroxide; sodium formate; trichlorophosphate;
In
chloroform; N,N-dimethyl-formamide;
