2-methyl-6-phenylpyrazine 4-oxide

Base Information

Chemical Name:2-methyl-6-phenylpyrazine 4-oxide
CAS No.:74428-47-0
Molecular Formula:C₁₁H₁₀N₂O
Molecular Weight:186.213
Hs Code.:

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Chemical Property of 2-methyl-6-phenylpyrazine 4-oxide

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Technology Process of 2-methyl-6-phenylpyrazine 4-oxide

There total 5 articles about 2-methyl-6-phenylpyrazine 4-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 74233-03-7
6-methyl-2-phenylpyrazine

: 74428-47-0
2-methyl-6-phenylpyrazine 4-oxide

: 2-methyl-6-phenylpyrazine 1,4-dioxide

Guidance literature:: With maleic anhydride; dihydrogen peroxide; In chloroform; 1.) overnight; 2.) reflux, 4 h;

Reference yield:

: 81225-11-8
2-chloro-3-methyl-5-phenylpyrazine

: 74428-47-0
2-methyl-6-phenylpyrazine 4-oxide

Guidance literature:: Multi-step reaction with 5 steps

1: 18 percent / 90percent H₂O₂, maleic anhydride / CHCl₃ / 1.) room temperature, overnight; 2.) reflux, 3 h

2: 95 percent / tetrakis(triphenylphosphine)palladium, sodium formate / dimethylformamide / 2 h / 100 °C

3: 31 percent / POCl₃ / 1 h / Heating

4: 74 percent / H₂, sodium acetate / 20percent Pd carbon / ethanol

5: 79 percent / 90percent H₂O₂, maleic anhydride / CHCl₃ / 1.) overnight; 2.) reflux, 4 h

With maleic anhydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; dihydrogen peroxide; sodium formate; sodium acetate; trichlorophosphate; palladium on activated charcoal; In ethanol; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 86731-84-2
3-hydroxy-2-methyl-6-phenylpyrazine

: 74428-47-0
2-methyl-6-phenylpyrazine 4-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / PCl₅, POCl₃ / 1 h / 140 °C / Heating; sealed tube

2: 74 percent / H₂, sodium acetate / 20percent Pd carbon / ethanol

3: 79 percent / 90percent H₂O₂, maleic anhydride / CHCl₃ / 1.) overnight; 2.) reflux, 4 h

With maleic anhydride; phosphorus pentachloride; hydrogen; dihydrogen peroxide; sodium acetate; trichlorophosphate; palladium on activated charcoal; In ethanol; chloroform;