isobutyl 1-methyl-1-(2-bromophenyl)ethyl ether

Base Information

• Chemical Name: isobutyl 1-methyl-1-(2-bromophenyl)ethyl ether
• CAS No.: 96897-83-5
• Molecular Formula: C₁₄H₂₁BrO₂
• Molecular Weight: 301.224
• Mol file: 96897-83-5.mol

Synonyms:

Chemical Property of isobutyl 1-methyl-1-(2-bromophenyl)ethyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of isobutyl 1-methyl-1-(2-bromophenyl)ethyl ether

There total 1 articles about isobutyl 1-methyl-1-(2-bromophenyl)ethyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloromethyl isobutyl ether (34180-11-5) + 2-(2-bromophenyl)propanol (7073-69-0) → isobutyl 1-methyl-1-(2-bromophenyl)ethyl ether (96897-83-5)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) THF, overnight, 2.) THF, 3 h;

DOI:10.1021/jo00216a021

Reference yield:

isobutyl 1-methyl-1-(2-bromophenyl)ethyl ether (96897-83-5) → 1-<(2-isopropenyl)phenyl>-10,10-dimethyl-5,10-dihydrodibenzophosphorin (96913-33-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) t-BuLi / 1.) THF, T<-60 deg C, 10 min, 2.) THF, 1 h

2: 86 percent / 2 N HCl / ethanol / Ambient temperature

3: 86 percent / 115percent polyphosphoric acid (PPA) / 0.5 h / 150 - 155 °C

4: 83 percent / HSiCl₃ / benzene / 5 h / Heating

5: 89 percent / 10percent P₂O₅/methanesulfonic acid (MSA) / 1 h / Ambient temperature

With hydrogenchloride; PPA; methanesulfonic acid; trichlorosilane; tert.-butyl lithium; phosphorus pentoxide; In ethanol; benzene;

DOI:10.1021/jo00216a021

Reference yield:

isobutyl 1-methyl-1-(2-bromophenyl)ethyl ether (96897-83-5) → 1-<2-(1-hydroxy-1-methylethyl)phenyl>-10,10-dimethyl-5,10-dihydrodibenzophosphorin (96897-86-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) t-BuLi / 1.) THF, T<-60 deg C, 10 min, 2.) THF, 1 h

2: 86 percent / 2 N HCl / ethanol / Ambient temperature

3: 86 percent / 115percent polyphosphoric acid (PPA) / 0.5 h / 150 - 155 °C

4: 83 percent / HSiCl₃ / benzene / 5 h / Heating

With hydrogenchloride; PPA; trichlorosilane; tert.-butyl lithium; In ethanol; benzene;

DOI:10.1021/jo00216a021

upstream raw materials:

chloromethyl isobutyl ether

2-(2-bromophenyl)propanol

Downstream raw materials:

bis<2-<1-(isobutoxymethoxy)-1-methylethyl>phenyl>phenylphosphine oxide

3,3,3',3'-tetramethyl-1-phenyl-1,1'-spirobi<3H-2,1-benzoxaphosphole>

1-<(2-isopropenyl)phenyl>-10,10-dimethyl-5,10-dihydrodibenzophosphorin

1-<2-(1-hydroxy-1-methylethyl)phenyl>-10,10-dimethyl-5,10-dihydrodibenzophosphorin

Refernces