4--4-oxo-butane carboxylic acid

Base Information

• Chemical Name: 4--4-oxo-butane carboxylic acid
• CAS No.: 154195-23-0
• Molecular Formula: C₁₄H₁₆N₂O₃
• Molecular Weight: 260.293
• Mol file: 154195-23-0.mol

Synonyms:

Chemical Property of 4--4-oxo-butane carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4--4-oxo-butane carboxylic acid

There total 1 articles about 4--4-oxo-butane carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.6%

succinic acid anhydride (108-30-5) + 3-(benzylamino)propionitrile (706-03-6) → 4--4-oxo-butane carboxylic acid (154195-23-0)

Guidance literature:

With sodium carbonate; In acetonitrile; for 4h; Heating;

DOI:10.1002/prac.19943360120

Reference yield:

4--4-oxo-butane carboxylic acid (154195-23-0) → 1-benzyl-6-cyano-5-hydroxy-3(H)-4(H)-7(H)-2-oxo-azepine

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 3 h / Ambient temperature

2: 10 h / Ambient temperature

3: 82.6 percent / t-BuOK / toluene / 4 h / 125 °C

With thionyl chloride; potassium tert-butylate; In toluene;

DOI:10.1002/prac.19943360120

Reference yield:

4--4-oxo-butane carboxylic acid (154195-23-0) → 3-[Benzyl-(2-cyano-ethyl)-carbamoyl]-propionyl chloride

Guidance literature:

With thionyl chloride; for 3h; Ambient temperature;

DOI:10.1002/prac.19943360120

upstream raw materials:

succinic acid anhydride

3-(benzylamino)propionitrile

Downstream raw materials:

ethyl-4- 4-oxo-butane carboxylic acid ester