methyl 2-phenylseleno-5,5,20,20-bis(ethylenedioxy)-3,5-seco-4-norpregnan-3-oate

Base Information

Chemical Name:methyl 2-phenylseleno-5,5,20,20-bis(ethylenedioxy)-3,5-seco-4-norpregnan-3-oate
CAS No.:326864-73-7
Molecular Formula:C₃₁H₄₄O₆Se
Molecular Weight:591.647
Hs Code.:

Synonyms:

Suppliers and Price of methyl 2-phenylseleno-5,5,20,20-bis(ethylenedioxy)-3,5-seco-4-norpregnan-3-oate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2-phenylseleno-5,5,20,20-bis(ethylenedioxy)-3,5-seco-4-norpregnan-3-oate

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Technology Process of methyl 2-phenylseleno-5,5,20,20-bis(ethylenedioxy)-3,5-seco-4-norpregnan-3-oate

There total 3 articles about methyl 2-phenylseleno-5,5,20,20-bis(ethylenedioxy)-3,5-seco-4-norpregnan-3-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57-83-0
Progesterone

: 326864-73-7
methyl 2-phenylseleno-5,5,20,20-bis(ethylenedioxy)-3,5-seco-4-norpregnan-3-oate

Guidance literature:: Multi-step reaction with 4 steps

1.1: O₃ / ethyl acetate

1.2: H₂O₂ / H₂O

2.1: 2.652 g / methanol

3.1: 84 percent / trimethyl orthoformate; PTSA / 20 °C

4.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

4.2: 91 percent / tetrahydrofuran / -78 - 20 °C

With toluene-4-sulfonic acid; ozone; lithium diisopropyl amide; trimethyl orthoformate; In tetrahydrofuran; methanol; ethyl acetate; 1.1: ozonolysis / 1.2: Reduction / 2.1: Methylation / 3.1: Cyclization / 4.1: Metallation / 4.2: Substitution;
DOI:10.1016/S0040-4020(00)00966-2

Reference yield:

: 3510-20-1
3,5-seco-4-norpregn-5,20-dion-3-carboxylic acid

: 326864-73-7
methyl 2-phenylseleno-5,5,20,20-bis(ethylenedioxy)-3,5-seco-4-norpregnan-3-oate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2.652 g / methanol

2.1: 84 percent / trimethyl orthoformate; PTSA / 20 °C

3.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

3.2: 91 percent / tetrahydrofuran / -78 - 20 °C

With toluene-4-sulfonic acid; lithium diisopropyl amide; trimethyl orthoformate; In tetrahydrofuran; methanol; 1.1: Methylation / 2.1: Cyclization / 3.1: Metallation / 3.2: Substitution;
DOI:10.1016/S0040-4020(00)00966-2

Reference yield:

: 210052-30-5
methyl 5,20-dioxo-3,5-seco-4-norpregnan-3-oate

: 326864-73-7
methyl 2-phenylseleno-5,5,20,20-bis(ethylenedioxy)-3,5-seco-4-norpregnan-3-oate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 84 percent / trimethyl orthoformate; PTSA / 20 °C

2.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

2.2: 91 percent / tetrahydrofuran / -78 - 20 °C

With toluene-4-sulfonic acid; lithium diisopropyl amide; trimethyl orthoformate; In tetrahydrofuran; 1.1: Cyclization / 2.1: Metallation / 2.2: Substitution;
DOI:10.1016/S0040-4020(00)00966-2