toluene-4-sulfonic acid 4-{[3-(anthracen-9-ylmethyl-tert-butoxycarbonylamino)propyl]-tert-butoxycarbonylamino}butyl ester

Base Information

• Chemical Name: toluene-4-sulfonic acid 4-{[3-(anthracen-9-ylmethyl-tert-butoxycarbonylamino)propyl]-tert-butoxycarbonylamino}butyl ester
• CAS No.: 569372-72-1
• Molecular Formula: C₃₉H₅₀N₂O₇S
• Molecular Weight: 690.901
• Mol file: 569372-72-1.mol

Synonyms:

Chemical Property of toluene-4-sulfonic acid 4-{[3-(anthracen-9-ylmethyl-tert-butoxycarbonylamino)propyl]-tert-butoxycarbonylamino}butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of toluene-4-sulfonic acid 4-{[3-(anthracen-9-ylmethyl-tert-butoxycarbonylamino)propyl]-tert-butoxycarbonylamino}butyl ester

There total 3 articles about toluene-4-sulfonic acid 4-{[3-(anthracen-9-ylmethyl-tert-butoxycarbonylamino)propyl]-tert-butoxycarbonylamino}butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

p-toluenesulfonyl chloride (98-59-9) + [3-(anthracen-9-ylmethyl-tert-butoxycarbonylamino)propyl](4-hydroxybutyl)carbamic acid tert-butyl ester (569372-68-5) → toluene-4-sulfonic acid 4-{[3-(anthracen-9-ylmethyl-tert-butoxycarbonylamino)propyl]-tert-butoxycarbonylamino}butyl ester (569372-72-1)

Guidance literature:

With pyridine; for 1h;

DOI:10.1021/jm020598g

Reference yield:

anthracen-9-ylmethyl[3-(4-hydroxybutylamino)propyl]carbamic acid tert-butyl ester (569372-62-9) → toluene-4-sulfonic acid 4-{[3-(anthracen-9-ylmethyl-tert-butoxycarbonylamino)propyl]-tert-butoxycarbonylamino}butyl ester (569372-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / pyridine / methanol / 0 - 20 °C

2: 70 percent / pyridine / 1 h

With pyridine; In methanol;

DOI:10.1021/jm020598g

Reference yield:

4-methylbenzenesulfonic acid 3-[(anthracen-9-ylmethyl)(tert-butoxycarbonyl)amino]propyl ester (561300-94-5) → toluene-4-sulfonic acid 4-{[3-(anthracen-9-ylmethyl-tert-butoxycarbonylamino)propyl]-tert-butoxycarbonylamino}butyl ester (569372-72-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 67 percent / acetonitrile / 75 °C

2: 82 percent / pyridine / methanol / 0 - 20 °C

3: 70 percent / pyridine / 1 h

With pyridine; In methanol; acetonitrile;

DOI:10.1021/jm020598g

upstream raw materials:

p-toluenesulfonyl chloride

[3-(anthracen-9-ylmethyl-tert-butoxycarbonylamino)propyl](4-hydroxybutyl)carbamic acid tert-butyl ester

anthracen-9-ylmethyl[3-(4-hydroxybutylamino)propyl]carbamic acid tert-butyl ester

4-methylbenzenesulfonic acid 3-[(anthracen-9-ylmethyl)(tert-butoxycarbonyl)amino]propyl ester