(E)-3-(5-Hydroxymethyl-1-trityl-1H-imidazol-4-yl)-acrylonitrile

Base Information

• Chemical Name: (E)-3-(5-Hydroxymethyl-1-trityl-1H-imidazol-4-yl)-acrylonitrile
• CAS No.: 82032-55-1
• Molecular Formula: C₂₆H₂₁N₃O
• Molecular Weight: 391.472
• Mol file: 82032-55-1.mol

Synonyms:

Chemical Property of (E)-3-(5-Hydroxymethyl-1-trityl-1H-imidazol-4-yl)-acrylonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-(5-Hydroxymethyl-1-trityl-1H-imidazol-4-yl)-acrylonitrile

There total 5 articles about (E)-3-(5-Hydroxymethyl-1-trityl-1H-imidazol-4-yl)-acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl imidazole-4,5-dicarboxylate (3304-70-9) → (E)-3-(5-Hydroxymethyl-1-trityl-1H-imidazol-4-yl)-acrylonitrile (82032-55-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 93 percent / triethylamine / dimethylformamide / 4 h / Ambient temperature

2: 85 percent / lithium aluminium hydride / tetrahydrofuran / 1.) 0 degC 30 min., 2.) R_.T_. 3 h

3: 62 percent / manganese dioxide / CHCl₃ / 3 h / Heating

4: sodium hydride / benzene / 1.) 0 degC, 2.) 45 degC 20 min.

With manganese(IV) oxide; lithium aluminium tetrahydride; sodium hydride; triethylamine; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; benzene;

DOI:10.1139/v82-107

Reference yield:

trityl chloride (76-83-5) → (E)-3-(5-Hydroxymethyl-1-trityl-1H-imidazol-4-yl)-acrylonitrile (82032-55-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 93 percent / triethylamine / dimethylformamide / 4 h / Ambient temperature

2: 85 percent / lithium aluminium hydride / tetrahydrofuran / 1.) 0 degC 30 min., 2.) R_.T_. 3 h

3: 62 percent / manganese dioxide / CHCl₃ / 3 h / Heating

4: sodium hydride / benzene / 1.) 0 degC, 2.) 45 degC 20 min.

With manganese(IV) oxide; lithium aluminium tetrahydride; sodium hydride; triethylamine; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; benzene;

DOI:10.1139/v82-107

Reference yield:

dimethyl 1-triphenylmethylimidazole-4,5-dicarboxylate (77134-73-7) → (E)-3-(5-Hydroxymethyl-1-trityl-1H-imidazol-4-yl)-acrylonitrile (82032-55-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / lithium aluminium hydride / tetrahydrofuran / 1.) 0 degC 30 min., 2.) R_.T_. 3 h

2: 62 percent / manganese dioxide / CHCl₃ / 3 h / Heating

3: sodium hydride / benzene / 1.) 0 degC, 2.) 45 degC 20 min.

With manganese(IV) oxide; lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; chloroform; benzene;

DOI:10.1139/v82-107

upstream raw materials:

diethyl 1-cyanomethylphosphonate

4-(5-hydroxymethyl-1-triphenylmethyl)imidazolecarboxaldehyde

dimethyl imidazole-4,5-dicarboxylate

trityl chloride