benzyl N-(5-phthalimidopentanoyl)-D-alanyl-D-isoglutaminate

Base Information

• Chemical Name: benzyl N-(5-phthalimidopentanoyl)-D-alanyl-D-isoglutaminate
• CAS No.: 736145-07-6
• Molecular Formula: C₂₈H₃₂N₄O₇
• Molecular Weight: 536.585
• Mol file: 736145-07-6.mol

Synonyms:

Chemical Property of benzyl N-(5-phthalimidopentanoyl)-D-alanyl-D-isoglutaminate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of benzyl N-(5-phthalimidopentanoyl)-D-alanyl-D-isoglutaminate

There total 1 articles about benzyl N-(5-phthalimidopentanoyl)-D-alanyl-D-isoglutaminate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(N-phthalimido)pentanoic acid (1147-76-8) → benzyl N-(5-phthalimidopentanoyl)-D-alanyl-D-isoglutaminate (736145-07-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 67 percent / diphenylphosphoryl azide; Et₃N / dimethylformamide / 51 h / 0 - 20 °C

2: 87 percent / H₂; glac. AcOH / Pd/C / 3 h

3: 75 percent / diphenylphosphoryl azide; Et₃N / dimethylformamide / 51 h / 0 - 20 °C

With diphenylphosphoranyl azide; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In N,N-dimethyl-formamide;

DOI:10.1016/j.farmac.2004.01.003

upstream raw materials:

5-(N-phthalimido)pentanoic acid