BOC-TYR-OSU

Base Information

• Chemical Name: BOC-TYR-OSU
• CAS No.: 20866-56-2
• Molecular Formula: C18H22 N2 O7
• Molecular Weight: 378.382
• Mol file: 20866-56-2.mol

Synonyms:Carbamicacid, [(1S)-2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1-[(4-hydroxyphenyl)methyl]-2-oxoethyl]-,1,1-dimethylethyl ester (9CI); Carbamic acid,[2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1-[(4-hydroxyphenyl)methyl]-2-oxoethyl]-,1,1-dimethylethyl ester, (S)-; Succinimide, N-[(N-carboxy-L-tyrosyl)oxy]-,tert-butyl ester (8CI); Tyrosine, N-carboxy-, N-tert-butyl ester, succinimidoderiv., L- (8CI); N-Hydroxysuccinimido tert-butyloxycarbonyltyrosinate; NSC334308; tert-Butyloxycarbonyl-L-tyrosine N-hydroxysuccinimide ester

Chemical Property of BOC-TYR-OSU

Chemical Property:

• Melting Point: -190oC (dec.)
• PSA: 122.24000
• Density: 1.35g/cm³
• LogP: 1.76400
• Storage Temp.: −20°C

Purity/Quality:

99% ^*data from raw suppliers

Boc-L-tyrosine N-hydroxysuccinimide ester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of BOC-TYR-OSU

There total 6 articles about BOC-TYR-OSU which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

Boc-Tyr-OH (3978-80-1) + bis(N-hydroxysuccinimide) sulfite (90704-86-2) → 2,5-dioxopyrrolidin-1-yl N-(tert-butoxycarbonyl)-L-tyrosinate (20866-56-2)

Guidance literature:

With pyridine; In acetonitrile; at 20 ℃; for 1.5h; further solvent, base;

DOI:10.1007/BF01141728

Reference yield: 74.0%

Boc-Tyr-OH (3978-80-1) + 1,2,2,2-tetrachloroethyl-(N-succinimidyl)carbonate (107960-02-1) → 2,5-dioxopyrrolidin-1-yl N-(tert-butoxycarbonyl)-L-tyrosinate (20866-56-2)

Guidance literature:

With 4-methyl-morpholine; In tetrahydrofuran; acetonitrile; Ambient temperature;

DOI:10.1021/jo00388a005

Reference yield:

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + Boc-Tyr-OH (3978-80-1) → 2,5-dioxopyrrolidin-1-yl N-(tert-butoxycarbonyl)-L-tyrosinate (20866-56-2)

Guidance literature:

With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; at 23 ℃; for 2h;

DOI:10.1002/1521-3765(20011001)7:19<4280::AID-CHEM4280>3.0.CO;2-3

upstream raw materials:

Boc-Tyr-OH

1,2,2,2-tetrachloroethyl-(N-succinimidyl)carbonate

bis(N-hydroxysuccinimide) sulfite

1-hydroxy-pyrrolidine-2,5-dione

Downstream raw materials:

Boc-Tyr-D-Ala-Phe-OH

Boc-Tyr-Thr-OCH₃

Boc-Tyr-Nle-Gly-OH

Boc-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH₂