(2'S,4S,5S)-2,2-dimethyl-5-<(tert-butyldimethylsilyloxy)methyl>-4-<2'-(4''-methylphenyl)thio>-1'-<(tert-butyloxycarbonyl)amino>-2'-oxoethyl-1,3-dioxolane

Base Information

Chemical Name:(2'S,4S,5S)-2,2-dimethyl-5-<(tert-butyldimethylsilyloxy)methyl>-4-<2'-(4''-methylphenyl)thio>-1'-<(tert-butyloxycarbonyl)amino>-2'-oxoethyl-1,3-dioxolane
CAS No.:157661-84-2
Molecular Formula:C₂₆H₄₃NO₆SSi
Molecular Weight:525.782
Hs Code.:

(2'S,4S,5S)-2,2-dimethyl-5-<(tert-butyldimethylsilyloxy)methyl>-4-<2'-(4''-methylphenyl)thio>-1'-<(tert-butyloxycarbonyl)amino>-2'-oxoethyl-1,3-dioxolane

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Chemical Property of (2'S,4S,5S)-2,2-dimethyl-5-<(tert-butyldimethylsilyloxy)methyl>-4-<2'-(4''-methylphenyl)thio>-1'-<(tert-butyloxycarbonyl)amino>-2'-oxoethyl-1,3-dioxolane

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Technology Process of (2'S,4S,5S)-2,2-dimethyl-5-<(tert-butyldimethylsilyloxy)methyl>-4-<2'-(4''-methylphenyl)thio>-1'-<(tert-butyloxycarbonyl)amino>-2'-oxoethyl-1,3-dioxolane

There total 7 articles about (2'S,4S,5S)-2,2-dimethyl-5-<(tert-butyldimethylsilyloxy)methyl>-4-<2'-(4''-methylphenyl)thio>-1'-<(tert-butyloxycarbonyl)amino>-2'-oxoethyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1054620-96-0
(S)-Amino-[(4S,5S)-5-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-thioacetic acid S-p-tolyl ester

: 157661-84-2
(2'S,4S,5S)-2,2-dimethyl-5-<(tert-butyldimethylsilyloxy)methyl>-4-<2'-(4''-methylphenyl)thio>-1'-<(tert-butyloxycarbonyl)amino>-2'-oxoethyl-1,3-dioxolane

: (2'R,4S,5S)-2,2-dimethyl-5-<(tert-butyldimethylsilyloxy)methyl>-4-<2'-(4''-methylphenyl)thio>-1'-<(tert-butyloxycarbonyl)amino>-2'-oxoethyl-1,3-dioxolane

Guidance literature:: In dichloromethane; for 2h; Ambient temperature;
DOI:10.1039/c39940000095

Reference yield:

: 108817-97-6
(4R,5S)-5-tert-butyldimethylsilyloxymethyl-2,2-dimethyl-1,3-dioxolane-4-carbaldehyde

: 157661-84-2
(2'S,4S,5S)-2,2-dimethyl-5-<(tert-butyldimethylsilyloxy)methyl>-4-<2'-(4''-methylphenyl)thio>-1'-<(tert-butyloxycarbonyl)amino>-2'-oxoethyl-1,3-dioxolane

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) t-BuOK, t-BuOH, 2.) MeSO₂Cl, i-Pr₂NEt / 1.) THF, room temperature, 2.5 h, 2.) CH₂Cl₂, -78 to room temperature, 2 h

2: n-BuLi, t-BuOOH / toluene; tetrahydrofuran / 1 h / -78 °C

3: 1.) aq. NH₃ / 1.) CH₂Cl₂, room temperature, 2 h, 2.) 0 deg C to room temperature

With tert.-butylhydroperoxide; ammonium hydroxide; n-butyllithium; potassium tert-butylate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; tert-butyl alcohol; In tetrahydrofuran; toluene;
DOI:10.1021/jo00125a032

Reference yield:

: 150640-22-5
<(4-methylphenyl)thio>nitromethane

: 157661-84-2
(2'S,4S,5S)-2,2-dimethyl-5-<(tert-butyldimethylsilyloxy)methyl>-4-<2'-(4''-methylphenyl)thio>-1'-<(tert-butyloxycarbonyl)amino>-2'-oxoethyl-1,3-dioxolane

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) t-BuOK, t-BuOH, 2.) MeSO₂Cl, i-Pr₂NEt / 1.) THF, room temperature, 2.5 h, 2.) CH₂Cl₂, -78 to room temperature, 2 h

2: n-BuLi, t-BuOOH / toluene; tetrahydrofuran / 1 h / -78 °C

3: 1.) aq. NH₃ / 1.) CH₂Cl₂, room temperature, 2 h, 2.) 0 deg C to room temperature

With tert.-butylhydroperoxide; ammonium hydroxide; n-butyllithium; potassium tert-butylate; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; tert-butyl alcohol; In tetrahydrofuran; toluene;
DOI:10.1021/jo00125a032