Technology Process of 4-carboxycarbonylamino-7-chloro-3-phenyl-2(1H)-quinolone
There total 7 articles about 4-carboxycarbonylamino-7-chloro-3-phenyl-2(1H)-quinolone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 61 percent / NH3 / methanol / 72 h / 150 °C / 22800 Torr
2: 1.) triethylamine, trifluoroacetic anhydride, 2.) potassium carbonate / 1.) THF, 0 deg C, 30 min, 2.) CH3OH, H2O, 70 deg C, 24 h
3: 44 percent / CH2Cl2 / 16 h / Heating
4: 33 percent / NaH / dimethylformamide / 3 h / 100 °C
5: 1.) NaH / 1.) THF, RT, 1 h, 2.) THF, a) RT, 2 h, b) reflux, 14 h
6: 1 N aq. NaOH / 0.08 h
With
sodium hydroxide; ammonia; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic anhydride;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9605492
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 44 percent / CH2Cl2 / 16 h / Heating
2: 33 percent / NaH / dimethylformamide / 3 h / 100 °C
3: 1.) NaH / 1.) THF, RT, 1 h, 2.) THF, a) RT, 2 h, b) reflux, 14 h
4: 1 N aq. NaOH / 0.08 h
With
sodium hydroxide; sodium hydride;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9605492
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) triethylamine, trifluoroacetic anhydride, 2.) potassium carbonate / 1.) THF, 0 deg C, 30 min, 2.) CH3OH, H2O, 70 deg C, 24 h
2: 44 percent / CH2Cl2 / 16 h / Heating
3: 33 percent / NaH / dimethylformamide / 3 h / 100 °C
4: 1.) NaH / 1.) THF, RT, 1 h, 2.) THF, a) RT, 2 h, b) reflux, 14 h
5: 1 N aq. NaOH / 0.08 h
With
sodium hydroxide; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic anhydride;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm9605492
