5900-59-4

Basic information

• Product Name: 2-amino-4-chlorobenzamide
• Synonyms: 2-amino-4-chlorobenzamide;2-amino-4-chlorobenzamide(SALTDATA: FREE);2-aMino-4-chlrobenzaMide;4-Chloroanthranilamide
• CAS NO: 5900-59-4
• Molecular Formula: C₇H₇ClN₂O
• Molecular Weight: 170.59628
• EINECS: 200-002-4
• Mol File: 5900-59-4.mol
• Article Data: 22

Chemical Properties

• Melting Point: 181.5 °C
• Boiling Point: 308.755 °C at 760 mmHg
• Flash Point: 140.531 °C
• Appearance: /
• Density: 1.394 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.644
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 15.48±0.50(Predicted)
• CAS DataBase Reference: 2-amino-4-chlorobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-4-chlorobenzamide(5900-59-4)
• EPA Substance Registry System: 2-amino-4-chlorobenzamide(5900-59-4)

Safety Data

• Statements: 43
• Safety Statements: 36/37
• Hazardous Substances Data: 5900-59-4(Hazardous Substances Data)

Usage

Uses

2-Amino-4-chlorobenzamide is a useful research chemical.

InChI:InChI=1/C7H7ClN2O/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3H,9H2,(H2,10,11)

Upstream product

• 34662-32-3 4-chloro-2-nitrobenzonitrile 
• 64-19-7 acetic acid 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 1499-21-4 Diphenylphosphinic chloride 
• 1397833-65-6 (2-amino-4-chlorophenyl) (benzotriazole-1-yl)methanone 
• 38487-86-4 2-amino-4-chlorobenzonitrile 
• 5551-11-1 4-Chloro-2-nitrobenzaldehyde 
• 6341-92-0 6-chloroisatin 
• 40928-13-0 4-chloroisatoic anhydride 
• 7439-89-6 iron 
• 497-19-8 sodium carbonate 
• 41994-91-6 4-chloro-2-nitrobenzoic amide 
• 89-63-4 4-Chloro-2-nitroaniline 
• 75-44-5 phosgene 

Downstream Products

• 57946-24-4 4-Chloro-2-trifluoromethanesulfonylamino-benzamide 
• 105189-27-3 7-Chloro-2-[3-(3-piperidin-1-ylmethyl-phenoxy)-propyl]-3H-quinazolin-4-one 
• 75158-06-4 N-(2-carbamoyl-5-chlorophenyl)aminoacetate 
• 1373510-89-4 C₁₄H₁₀ClN₃O₄ 
• 1221128-83-1 7-chloro-2-(4-(trifluoromethyl)phenyl)quinazolin-4(3H)-one 
• 1221129-13-0 7-morpholino-2-(4-(trifluoromethyl)phenyl)quinazolin-4(3H)-one 
• 52910-89-1 2-(4-Nitrobenzamido)benzamide 
• 19407-65-9 7-chloro-2-(4-nitrophenyl)quinazolin-4(3H)-one 
• 34637-85-9 2-(3-nitrophenyl)-(3H)-4-quinazolinone 
• 36567-87-0 2-(2'-nitrophenyl)-4(3H)-quinazolinone 
• 50995-73-8 2-(3-amino-phenyl)-3H-quinazolin-4-one 
• 27259-73-0 2-(2'-aminophenyl)-4(3H)-quinazolinone 
• 67718-36-9 N-[2-(aminocarbonyl)phenyl]-2-nitrobenzamide 

Relevant articles and documents

Copper-Catalyzed One-Pot Synthesis of Quinazolinones from 2-Nitrobenzaldehydes with Aldehydes: Application toward the Synthesis of Natural Products

A novel, efficient, and atom-economical approach for the construction of quinazolinones from 2-nitrobenzaldehydes has been unveiled via copper-catalyzed nitrile formation, hydrolysis, and reduction in one pot for the first time. In this reaction, urea is used as a source of nitrogen for nitrile formation, hydrazine hydrate is used for both the reduction of the nitro group and the hydrolysis of nitrile, and atmospheric oxygen is used as the sole oxidant. The method portrays a wide substrate scope with good functional group tolerances. Moreover, this method was applied for the synthesis of schizocommunin, tryptanthrin, phaitanthrin-A, phaitanthrin-B, and 8H-quinazolino[4,3-b]quinazolin-8-one.

Visible-light induced copper(i)-catalyzed oxidative cyclization of: O -aminobenzamides with methanol and ethanol via HAT

The use of the in situ generated ligand-copper superoxo complex absorbing light energy to activate the alpha C(sp3)-H of MeOH and EtOH via the hydrogen atom transfer (HAT) process for the synthesis of quinazolinones by oxidative cyclization of alcohols with o-aminobenzamide has been investigated. The synthetic utility of this protocol offers an efficient synthesis of a quinazolinone intermediate for erlotinb (anti-cancer agent) and 30 examples were reported.

Synthesis and nematicidal evaluation of 1,2,3-benzotriazin-4-one derivatives containing piperazine as linker against Meloidogyne incognita

To explore new skeleton with nematicidal activity, a series of novel 1,2,3-benzotriazin-4-one derivatives containing piperazine as linker were synthesized and varied fragments were also introduced to increase structure diversity of the new skeleton. Their inhibitory activities in vivo were evaluated against Meloidogyne incognita. The newly prepared compounds A6, A8, A21, A28 and A38 exhibited more than 50% inhibition at the concentration of 20 mg/L. Especially compound A6 displayed 71.4% inhibition against Meloidogyne incognita at the concentration of 20 mg/L. The nematicidal activities varied significantly depending on the types and positions of the substituents, which provided guidance for further structure modification.