Technology Process of chloro-4-pentadecylphenylmethyl phosphonic acid
There total 8 articles about chloro-4-pentadecylphenylmethyl phosphonic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
chloro-4-pentadecylphenylmethyl phosphonic acid dimethyl ester;
With
trimethylsilyl bromide;
In
acetonitrile;
for 1h;
Reflux;
Inert atmosphere;
With
methanol;
at 20 ℃;
for 0.5h;
Inert atmosphere;
DOI:10.1002/cmdc.201000425
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 20 % Pd(OH)2/C; hydrogen / methanol / 2 h / 20 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere
3.1: dipyridinium dichromate / dichloromethane / 16 h / 20 °C / Inert atmosphere
4.1: triethylamine / 4 h / 0 - 20 °C / Inert atmosphere
5.1: thionyl chloride / dichloromethane / 1 h / Reflux; Inert atmosphere
6.1: trimethylsilyl bromide / acetonitrile / 1 h / Reflux; Inert atmosphere
6.2: 0.5 h / 20 °C / Inert atmosphere
With
lithium aluminium tetrahydride; dipyridinium dichromate; thionyl chloride; trimethylsilyl bromide; 20 % Pd(OH)2/C; hydrogen; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; acetonitrile;
4.1: Pudovic reaction;
DOI:10.1002/cmdc.201000425
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: palladium diacetate; triethylamine / N,N-dimethyl-formamide / 16 h / Reflux; Inert atmosphere
2.1: 20 % Pd(OH)2/C; hydrogen / methanol / 2 h / 20 °C
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere
4.1: dipyridinium dichromate / dichloromethane / 16 h / 20 °C / Inert atmosphere
5.1: triethylamine / 4 h / 0 - 20 °C / Inert atmosphere
6.1: thionyl chloride / dichloromethane / 1 h / Reflux; Inert atmosphere
7.1: trimethylsilyl bromide / acetonitrile / 1 h / Reflux; Inert atmosphere
7.2: 0.5 h / 20 °C / Inert atmosphere
With
lithium aluminium tetrahydride; dipyridinium dichromate; thionyl chloride; trimethylsilyl bromide; 20 % Pd(OH)2/C; hydrogen; palladium diacetate; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
1.1: Heck reaction / 5.1: Pudovic reaction;
DOI:10.1002/cmdc.201000425
