methyl 3-(N-(1-(5-nitropyridin-2-yl)piperidin-4-yl)-N-(4-((2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl)benzyl)sulfamoyl)thiophene-2-carboxylate

Base Information

Chemical Name:methyl 3-(N-(1-(5-nitropyridin-2-yl)piperidin-4-yl)-N-(4-((2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl)benzyl)sulfamoyl)thiophene-2-carboxylate
CAS No.:1404098-39-0
Molecular Formula:C₂₈H₂₆N₆O₉S₂
Molecular Weight:654.681
Hs Code.:

methyl 3-(N-(1-(5-nitropyridin-2-yl)piperidin-4-yl)-N-(4-((2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl)benzyl)sulfamoyl)thiophene-2-carboxylate

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Chemical Property of methyl 3-(N-(1-(5-nitropyridin-2-yl)piperidin-4-yl)-N-(4-((2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl)benzyl)sulfamoyl)thiophene-2-carboxylate

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Technology Process of methyl 3-(N-(1-(5-nitropyridin-2-yl)piperidin-4-yl)-N-(4-((2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl)benzyl)sulfamoyl)thiophene-2-carboxylate

There total 8 articles about methyl 3-(N-(1-(5-nitropyridin-2-yl)piperidin-4-yl)-N-(4-((2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl)benzyl)sulfamoyl)thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.3%

: 67-52-7,944357-77-1
BARBITURIC ACID

: 1404097-64-8
methyl 3-(N-(4-formylbenzyl)-N-(1-(5-nitropyridin-2-yl)piperidin-4-yl)sulfamoyl)thiophene-2-carboxylate

: 1404098-39-0
methyl 3-(N-(1-(5-nitropyridin-2-yl)piperidin-4-yl)-N-(4-((2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl)benzyl)sulfamoyl)thiophene-2-carboxylate

Guidance literature:: In ethanol; water; at 80 ℃; Reflux;
DOI:10.1021/jm301164y

Reference yield:

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 1404098-39-0
methyl 3-(N-(1-(5-nitropyridin-2-yl)piperidin-4-yl)-N-(4-((2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl)benzyl)sulfamoyl)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 80 °C

2: dichloromethane / 3 h / 0 - 25 °C

3: potassium carbonate / ethanol; water / 25 - 80 °C

4: sodium tetrahydroborate / methanol / 0.5 h / 0 - 60 °C

5: hydrogenchloride / water; acetone / 0.5 h

6: triethylamine / dichloromethane / 20 - 25 °C

7: ethanol; water / 80 °C / Reflux

With hydrogenchloride; sodium tetrahydroborate; potassium carbonate; triethylamine; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm301164y

Reference yield:

: C₂₂H₃₀N₄O₄

: 1404098-39-0
methyl 3-(N-(1-(5-nitropyridin-2-yl)piperidin-4-yl)-N-(4-((2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)methyl)benzyl)sulfamoyl)thiophene-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water; acetone / 0.5 h

2: triethylamine / dichloromethane / 20 - 25 °C

3: ethanol; water / 80 °C / Reflux

With hydrogenchloride; triethylamine; In ethanol; dichloromethane; water; acetone;
DOI:10.1021/jm301164y