(+)-CIS-(2R,3S)-3-Hydroxyproline

Base Information

Chemical Name:(+)-CIS-(2R,3S)-3-Hydroxyproline
CAS No.:118492-86-7
Molecular Formula:C5H9NO3
Molecular Weight:131.131
Hs Code.:
Mol file:118492-86-7.mol

Synonyms:cis-(2S,3R)-3-hydroxyproline;(2R,3R)-3-hydroxyproline;(2S,3R)-hydroxyproline;(2S,3R)-3-hydroxyproline;(R)-3-hydroxyproline;cis-3-hydroxy-L-proline;

Suppliers and Price of (+)-CIS-(2R,3S)-3-Hydroxyproline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(2R,3S)-3-Hydroxypyrrolidine-2-carboxylicAcid
50mg
$ 285.00

TRC
(2R,3S)-3-Hydroxypyrrolidine-2-carboxylicAcid
10mg
$ 65.00

TRC
(2R,3S)-3-Hydroxypyrrolidine-2-carboxylicAcid
5mg
$ 45.00

Synthonix
(2R,3S)-3-Hydroxypyrrolidine-2-carboxylicacid 95+%
1g
$ 1020.00

Synthonix
(2R,3S)-3-Hydroxypyrrolidine-2-carboxylicacid 95+%
500mg
$ 680.00

Synthonix
(2R,3S)-3-Hydroxypyrrolidine-2-carboxylicacid 95+%
10g
$ 5430.00

Synthonix
(2R,3S)-3-Hydroxypyrrolidine-2-carboxylicacid 95+%
5g
$ 3210.00

Synthonix
(2R,3S)-3-Hydroxypyrrolidine-2-carboxylicacid 95+%
250mg
$ 340.00

J&W Pharmlab
(2R,3S)-3-Hydroxy-pyrrolidine-2-carboxylicacid 97%
1g
$ 798.00

J&W Pharmlab
(2R,3S)-3-Hydroxy-pyrrolidine-2-carboxylicacid 97%
250mg
$ 275.00

Total 18 raw suppliers

Chemical Property of (+)-CIS-(2R,3S)-3-Hydroxyproline

Chemical Property:

Melting Point:240-255℃ (dec.)
Boiling Point:355.2±42.0 °C(Predicted)
PKA:2.03±0.40(Predicted)
PSA：69.56000
Density:1.395±0.06 g/cm3 (20 oC 760 Torr)
LogP:-0.87740
Storage Temp.:2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

(2R,3S)-3-Hydroxypyrrolidine-2-carboxylicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (+)-CIS-(2R,3S)-3-Hydroxyproline

There total 32 articles about (+)-CIS-(2R,3S)-3-Hydroxyproline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 567-35-1,567-36-2,4298-05-9,4298-06-0,4298-08-2,14916-76-8,62182-84-7,104069-26-3,118492-86-7,119677-21-3
(2S,3R)-3-hydroxyproline

Guidance literature:: With ferrous(II) sulfate heptahydrate; cis-3-proline hydroxylase type II; sodium L-ascorbate; at 37 ℃; for 16h; stereospecific reaction;
DOI:10.3762/bjoc.7.193

Reference yield: 98.0%

: 1262015-07-5
(2S,3R)-N-(benzyloxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid

: 567-35-1,567-36-2,4298-05-9,4298-06-0,4298-08-2,14916-76-8,62182-84-7,104069-26-3,118492-86-7,119677-21-3
(2S,3R)-3-hydroxyproline

Guidance literature:: With hydrogen; palladium(II) hydroxide; In methanol; at 25 ℃; for 12h; under 4137.29 Torr;
DOI:10.1016/j.tetlet.2010.10.086

Reference yield: 90.0%

: 166383-67-1
(2S,3R)-1-(tert-butoxycarbonyl)-3-(tert-butyldimethylsiloxy)pyrrolidine-2-carboxylic acid

: 567-35-1,567-36-2,4298-05-9,4298-06-0,4298-08-2,14916-76-8,62182-84-7,104069-26-3,118492-86-7,119677-21-3
(2S,3R)-3-hydroxyproline

Guidance literature:: (2S,3R)-1-(tert-butoxycarbonyl)-3-(tert-butyldimethylsiloxy)pyrrolidine-2-carboxylic acid; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h;

With methyloxirane; In methanol; at 20 ℃; for 2h;