L-Proline, 3-hydroxy-, methyl ester, (3R)- (9CI)

Base Information

Chemical Name:L-Proline, 3-hydroxy-, methyl ester, (3R)- (9CI)
CAS No.:496841-08-8
Molecular Formula:C6H11NO3
Molecular Weight:145.158
Hs Code.:
Mol file:496841-08-8.mol

Synonyms:L-Proline, 3-hydroxy-, methyl ester, (3R)- (9CI);L-PROLINE-3-(R)-HYDROXY METHYL ESTER

Suppliers and Price of L-Proline, 3-hydroxy-, methyl ester, (3R)- (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Synthonix
Methyl(2S,3R)-3-hydroxypyrrolidine-2-carboxylate 95+%
1g
$ 1080.00

Matrix Scientific
Methyl(2S,3R)-3-hydroxypyrrolidine-2-carboxylate 95+%
1g
$ 1304.00

Total 9 raw suppliers

Chemical Property of L-Proline, 3-hydroxy-, methyl ester, (3R)- (9CI)

Chemical Property:

Vapor Pressure:0.00426mmHg at 25°C
Refractive Index:1.487
Boiling Point:247.2°C at 760 mmHg
Flash Point:103.3°C
PSA：58.56000
Density:1.216g/cm³
LogP:-0.78900

Purity/Quality:

97% ^*data from raw suppliers

Methyl(2S,3R)-3-hydroxypyrrolidine-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Proline, 3-hydroxy-, methyl ester, (3R)- (9CI)

There total 4 articles about L-Proline, 3-hydroxy-, methyl ester, (3R)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 567-35-1,567-36-2,4298-05-9,4298-06-0,4298-08-2,14916-76-8,62182-84-7,104069-26-3,118492-86-7,119677-21-3
(2S,3R)-3-hydroxyproline

: 496841-08-8,1378292-24-0
cis-3-hydroxy-L-proline methyl ester

Guidance literature:: With acetyl chloride; at 20 ℃;
DOI:10.1021/acschemneuro.0c00005

Reference yield:

: 35684-61-8,35684-62-9,92246-87-2
(2S,3R)-3-Hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester

: 496841-08-8,1378292-24-0
cis-3-hydroxy-L-proline methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 1h; Ambient temperature;
DOI:10.1021/jm00021a013

Reference yield:

: 1262015-07-5
(2S,3R)-N-(benzyloxycarbonyl)-3-hydroxypyrrolidine-2-carboxylic acid

: 496841-08-8,1378292-24-0
cis-3-hydroxy-L-proline methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Amberlyst 15 / Ambient temperature

2: H₂ / 10percent Pd/C / methanol / 1 h / Ambient temperature

With Amberlyst 15; hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00021a013